Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000599
Title: Anti-nociceptive Activity of the Fruits of Swietenia macrophylla King.
Category: Pharmacology
Section: Research Article
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  • Abstract

    Fruits of Swietenia macrophylla King (Meliaceae) are used in Malay folk medicine as pain killer. The antinociceptive effect of ethanol and aqueous extracts was assessed by oral administration in acetic acid induced writhing, tail immersion and hot plate tests in mice. The ethanol extract 200 mg/kg treated group reduces the number of writhing on animal model, showed powerful anti-nociceptive effect (P < 0.01). Also the significant (P < 0.01) analgesic activity of S. macrophylla ethanolic extract at the dose of 200 mg/kg was further confirmed by tail-flick response and hot-plate response (P < 0.01).S. macrophylla extract produce analgesic in chemical and thermal pain models through a mechanism partially linked to either lipooxygenase and/or cyclooxygenase via the arachidonic acid cascade and/or opioid receptors. Our results corroborate the analgesic effects of S.macrophylla, and confirm its traditional use for treating pain.

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    Author(s) Name:

    Amitava Das *, J.Anbu Jeba Sunilson, Rejitha Gopinath, Suraj Radhamani, Kiran Nilugal

    Affiliation(s) Name:

    *School of Pharmacy, Masterskill University College of Health Sciences, 43200, Batu 9, Cheras, Selangor, Malaysia.


    Received on: 27-04-2009; Accepted on: 29-07-2009

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    Author:

    Amitava Das *, J.Anbu Jeba Sunilson, Rejitha Gopinath, Suraj Radhamani, Kiran Nilugal

    Title:Anti-nociceptive Activity of the Fruits of Swietenia macrophylla King.
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (September)
    Year:2009
    Page No: (1367-1369)
  • Experimental Methods Keywords

    Methodology:Anti-nociceptive Activity
    Research Materials:Swietenia macrophylla

Keywords

Swietenia macrophylla; analgesic; ethanol extract; folklore claim

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