Journal: Journal of Pharmacy Research

Article Id: JPRS-PP-000060
Title: Pharmacokinetics and pharmacodynamics of Atorvastatin alone and in combination with Lercanidipine in hyperlipidemic rats
Category: Pharmacokinetics and Pharmacodynamics
Section: Research Article
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    The present study was carried out to investigating the pharmacokinetics and pharmacodynamics of atorvastatin (AT) alone and in combination with lercanidipine (LER) in hyperlipidemic rats. The standard cholesterol diet was used to induce hyperlipidemia in Wister rats. The blood samples were collected (on 1st and 8th day) from AT alone and in combination with LER treated groups and were analyzed for various pharmacokinetic parameters and lipid profiles. Atorvastatin caused a marked reduction in the lipid profiles in hyperlipidemic rats. The combination of AT and LER in hyperlipidemic rats produced a significant change in lipid profiles (pharmacodynamics) and insignificant change in the pharmacokinetics of atorvastatin when compared with AT alone. The results of present study, suggests synergistic activity of lercanidipine with atorvastatin.

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    Author(s) Name:

    Prasanna Kumar Katnapally1, Anbu Janaki1, Rama Narsimha Reddy Anreddy2 and Narsimha Reddy Yellu2*

    Affiliation(s) Name:

    1Department of Pharmacology, Vel’s college of pharmacy,Chennai, INDIA– 600 117.
    *2Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, INDIA - 506 009


    *For correspondence: Dr. Narsimha Reddy Yellu


    E-mail:yellu_nr @yahoo.com

    Received on:11-08-2008; Accepted on :11-11-2008

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    Author:

    Prasanna Kumar Katnapally1, Anbu Janaki1, Rama Narsimha Reddy Anreddy2 and Narsimha Reddy Yellu2*

    Title:Pharmacokinetics and pharmacodynamics of Atorvastatin alone and in combination with Lercanidipine in hyperlipidemic rats
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (January )
    Year:2009
    Page No: (66-70)
  • Experimental Methods Keywords

    Methodology:Pharmacokinetic Analysis, Pharmacodynamic Study
    Research Materials:Atorvastatin, lercanidipine

Keywords

Atorvastatin lercanidipine hyperlipidemia and lipid lowering activity

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