Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000605
Title: Studies on Hepatoprotective Activity of Ethanolic Extracts of Fruit pulp of Aegle marmelos (L.) Corr.
Category: Pharmacology
Section: Research Article
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    A number of ethnomedicinal plants and herbal preparations are used in traditional system of medicine for the management of hepatic disorders. However, many of them have not been investigated to volarize the traditional claims. Aegle marmelos (L.) Corr. is widely used in the treatment of hepatitis in folk medicine. Owing to its overwhelming ethnomedicinal significance, an attempt has been made to investigate effect of fruit pulp of A. marmelos for hepatoprotective activity. Hepatoprotective activities of ethanolic and aqueous extracts of fruit pulp of A. marmelos were examined against CCl4 induced liver damage in mice using silymarin as control. Enzyme activities of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT) and Alkaline Phosphatase (ALP) were analyzed. Results indicate that ethanolic and aqueous fruit pulp extracts of A. marmelos had moderate to significant activity over CCl4 treatment as compared to the control. Results of the present investigation suggest that CCl4 induced liver damage in rats can substantially be ameliorated by treatment of ethanolic extracts from fruit pulp of A. marmelos. Also the study confirms the claim on this plant as a potential hepatoprotective agent in the traditional medicine.

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    Author(s) Name:

    C. Rajasekaran1*, T. Kalaivani1, S. Ramya1 and R. Jayakumararaj2

    Affiliation(s) Name:

    *1School of Bio-Sciences and Technology,Chemical and Biomedical Engineering, VIT University, Vellore – 632 014.
    2 Department of Biotechnology, Raja Doraisingam Government Arts College, Sivagangai – 630561

    Received on: 29-04-2009; Accepted on: 20-06-2009

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    Author:

    C. Rajasekaran1*, T. Kalaivani1, S. Ramya1 and R. Jayakumararaj2

    Title:Studies on Hepatoprotective Activity of Ethanolic Extracts of Fruit pulp of Aegle marmelos (L.) Corr.
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (September)
    Year:2009
    Page No: (1419-1423)
  • Experimental Methods Keywords

    Methodology:Hepatoprotective activity; Serum Glutamate Oxaloacetate Transaminase (SGOT); Serum Glutamate Pyruvate Transaminase (SGPT); Alkaline Phosphatase (ALP).
    Research Materials:Aegle marmelos

Keywords

Aegle marmelos; Fruit pulp; Hepatoprotective activity; Serum Glutamate Oxaloacetate Transaminase (SGOT); Serum Glutamate Pyruvate Transaminase (SGPT); Alkaline Phosphatase (ALP).

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