Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000611
Title: Indomethacin solid dispersions by kneading method with lactose monohydrate and different polymers.
Category: Pharmaceutics
Section: Research Article
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    Indomethacin (IM) is one of the most widely used non-steroidal anti-inflammatory active pharmaceutical agent. However, its limited aqueous solubility and poor flowability creates bioavailability and formulation related problems. Role of various water-soluble carriers was studied for dissolution enhancement of a poorly soluble model drug, Indomethacin, using solid dispersion approach. Solid dispersions of Indomethacin with lactose monohydrate and different polymers Polyethylene glycol- 6000(PEG), Hydroxy Propyl Methyl Cellulose (HPMC), Polyvinyl Pyrrolidine (Povidone-30), and Beta Cyclodextrin (BCD) were prepared by kneading method. In the present investigation by keeping the constant amount of lactose monohydrate the effect of different hydrophilic polymers on solubility and dissolution were studied. The prepared solid dispersions were evaluated for content, saturation solubility, and dissolution and flowability parameters. Powdered solid dispersion with lactose monohydrate and used hydrophilic polymers showed approximately 10-20 fold increases in solubility over the pure drug. The all prepared solid dispersions shows improvement in dissolution profile and flowability compared to the raw indomethacin. Thus, the bioavailability of this poorly water-soluble drug and their flowability was greatly enhanced by formulation as solid dispersions with different hydrophilic polymers.

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    Author(s) Name:

    V.B.Yadav1* and A.V.Yadav2

    Affiliation(s) Name:

    1 Govt.College of Pharmacy, Vidya nagar, Karad, Dist-Satara (MS), India.
    2 Professor in pharmaceutics, Goa college of Pharmacy, Panaji.


    Received on: 22-05-2009; Accepted on:29-07-2009

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    Author:

    V.B.Yadav1* and A.V.Yadav2

    Title:Indomethacin solid dispersions by kneading method with lactose monohydrate and different polymers.
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (September)
    Year:2009
    Page No: (1498-1492)
  • Experimental Methods Keywords

    Methodology:kneading method, olubility; hydrophlic polymers; dissolution
    Research Materials:Indomethacin

Keywords

Indomethacin; kneading; solubility; hydrophlic polymers; dissolution

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