Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000613
Title: Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats
Category: Pharmacology
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    Background: Diabetic oxidative stress coexists with a reduction in the antioxidant status, which can further increase the harmful effects of free radicals. Zinc, an essential trace element succeeding iron in the human system, has pivotal role in the synthesis, storage and functional aspects of insulin. Recently, we have designed, synthesized and characterized a novel zinc complex with silibinin as an organic ligand and evaluated its antidiabetic efficacy in high fat fed- low dose STZ induced experimental diabetes in rats. Methods: Diabetic rats were treated with the zinc-silibinin complex (5mg/kg b.w./rat/day) for 30 days showed a significant reduction in the levels of fasting blood glucose, glycosylated hemoglobin (HbA1c) and plasma insulin. The antidiabetic activity of the complex was comparable with metformin, a standard antidiabetic drug. Further, the extent of oxidative stress and the levels of enzymatic and non-enzymatic antioxidants were assayed in control and experimental groups of rats. The levels of proinflammatory cytokines such as (NF)-κB p65, tumor necrosis factors (TNF)-α, interleukin (IL) - 1α and IL-6 were also determined. Pancreatic tissue was subjected to histological observations. Results and Discussion: Oral administration of zinc-silibinin complex significantly controlled the oxidative stress and improved the levels of both enzymatic and non- enzymatic antioxidants. Further, the expression of increased levels of pro-inflammatory markers is also decreased. Histological observations revealed that the zinc-silibinin complex effectively protects pancreatic β- cells against oxidative damage. The results of the present study indicate that the zinc-silibinin complex possess significant antioxidative as well as anti-inflammatory properties.Conclusion: Zinc-silibinin complex significantly ameliorates the chronic hyperglycemia induced oxidative stress in experimental diabetes. The levels of proinflammatory cytokines also provide further evidence for the antioxidant properties of zinc-silibinin complex. Histological observations made on the pancreatic tissues indicate the beneficial as well as the tissue protective nature of zinc-silibinin complex.

    Cite this article as: Jaishanker Umamaheswari and Sorimuthu Pillai Subramanian,Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats,Journal of Pharmacy Research 2015,9(4),288-298

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    Author(s) Name:

    Jaishanker Umamaheswari and Sorimuthu Pillai Subramanian*

    Affiliation(s) Name:

    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India.

    *Corresponding author.
    Dr. S. Subramanian
    Professor
    Department of Biochemistry
    University of Madras
    Guindy Campus
    Chennai 600 025,India.


    Received on:25-02-2015;Revised on: 18-04-2015 ; Accepted on:15-05-2015

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    Author:

    Jaishanker Umamaheswari and Sorimuthu Pillai Subramanian*

    Title:Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats
    Journal:Journal of Pharmacy Research
    Vol(issue):9(4)
    Year:2015
    Page No: (288-298)
  • Experimental Methods Keywords

    Methodology:antioxidant, cytokines, pancreatic tissue.
    Research Materials:zinc-silibinin

Keywords

Streptozotocin zinc-silibinin antioxidant cytokines pancreatic tissue.

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