Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000615
Title: Anti-inflammatory activity of aqueous extract of Cinnamomum tamala leaves by in vivo and in vitro methods
Category: Pharmacognosy and Herbal Drugs related study
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  • Abstract

    Cinnamomum tamala (Family- Lauraceae) was used traditionally in the treatment of inflammation but there is no scientific evidence exists to validate the folkloric use of the plant. Thus the present work was aimed at investigating the anti-inflammatory effect of the aqueous extract of Cinnamomum tamala leaves (CTW) by various in vivo and in vitro screening methods. CTW at dose of 100, 200 and 400mg/kg was evaluated in acute inflammation against carrageenan induced paw edema in rats and acetic acid-induced vascular permeability in mice. In vitro anti-inflammatory activity of CTW extract (concentrations 0.2 – 1 mg/ml) was studied by membrane stabilizing activity i.e. red blood cells (RBC’s) exposed to hypotonic solution In vitro experiment was performed in triplicate to minimize the errors. Results were analyzed by One-way ANOVA followed by Dunnett’s test P

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    Author(s) Name:

    Manoj Nilkant Gambhire*, Archana Ramesh Juvekar, Shaijesh Shirish Wankhede

    Affiliation(s) Name:

    *Department of Pharmaceutical Sciences and Technology, University Institute of Chemical
    Technology (UICT), Nathalal Parikh Marg, Matunga (E), Mumbai-400019, India.


    Received on:18-05-2009; Accepted on:25-07-2009

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    Author:

    Manoj Nilkant Gambhire*, Archana Ramesh Juvekar, Shaijesh Shirish Wankhede

    Title:Anti-inflammatory activity of aqueous extract of Cinnamomum tamala leaves by in vivo and in vitro methods
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (September)
    Year:2009
    Page No: (1521-1524)
  • Experimental Methods Keywords

    Methodology:Acute, inflammation, membrane stabilization, vascular permeability
    Research Materials:Cinnamomum tamala

Keywords

Acute inflammation membrane stabilization vascular permeability

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