Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-0000617
Title: Derivative Spectrophotometric Method for Simultaneous Estimation of nicotine and Bupropion Hydrochloride in Synthetic Mixture by Derivative Spectrophotometric Method
Category: Pharmaceutical Analysis
Section: Research Article
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  • Abstract

    The use of first order derivative spectroscophotometry allowed simultaneous determination of nicotine and bupropion hydrochloride in fixed dose combination products. The absorbance values at 251.2 nm and 259.8 nm of first derivative spectrum was used for the estimation of nicotine and bupropion hydrochloride, respectively without mutual interference. This method obeyed Beer’s law in the concentration range of 10-30 µg/ml for both nicotine and bupropion hydrochloride. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.

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    Author(s) Name:

    K.N Patel*1, Dr.J.K.Patel1 ,I.S.Rathod2

    Affiliation(s) Name:

    1Nootan Pharmacy College, visnagar-384315.
    2Department of Pharmaceutical analysis, L.M.College of Pharmacy, Navrangpura, Ahmedabad-380009.


    Received on: 22-05-2009; Accepted on:26-07-2009

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    Author:

    K.N Patel*1, Dr.J.K.Patel1 ,I.S.Rathod2

    Title:Derivative Spectrophotometric Method for Simultaneous Estimation of nicotine and Bupropion Hydrochloride in Synthetic Mixture by Derivative Spectrophotometric Method
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (September)
    Year:2009
    Page No: (1525-1527)
  • Experimental Methods Keywords

    Methodology:Derivative Spectrophotometric Method
    Research Materials:Nicotine, Bupropion hydrochloride

Keywords

Nicotine Bupropion hydrochloride Phosphate buffer Ultra-violet spectrophotometry Derivative spectrophotometry.

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