Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000618
Title: Development of Non-Bitter Zolpidem Tartrate Mouth Dissolving Tablet
Category: Pharmaceutics
Section: Editorial
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    Purpose: Zolpidem tartrate is a centrally acting potent hypnotic agent. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless mouth dissolving tablets of Zolpidem tartrate using ion exchange resin Tulsion 335 as a taste masking agent. Method: Ion exchange resinates and tasteless granules were prepared with Tulsion 335 in weight ratio of 1:3. Resinates and granules were evaluated for its taste sensation in human volunteers. Prepared complex was further examined through IR, DSC and XRD curves. The mouth dissolving tablets of both resinates and granules were prepared with two superdisintegrants e.g. crosscarmellose sodium and crospovidone in different concentration. The blend was examined for their flow properties. The tablets were evaluated for physiochemical properties. Pure drug and tablets were also evaluated loss of righting reflux in albino Mice.Results: The tasteless blends having good flow properties. The prepared zero defect mouth dissolving tablets were passed all the official and non-official parameters. The disintegration time was also tested and was found to be less than one minute. A tablet having resinates shows less time for onset of action of drug due to enhanced and fast release of Zolpidem Tartrate. Conclusion: It was concluded that tablets prepared by addition of superdisintegrant crospovidone has less disintegration time, fast and more dug release than those prepared by crosscarmelose sodium; which was also further founded in the in-vivo investigation.

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    Author(s) Name:

    Rajnibala*, Shailesh Sharma, Neelam Sharma, Ghanshyam Das Gupta

    Affiliation(s) Name:

    *Dosage form Designing Laboratory,Department of Pharmaceutics,ASBASJSM College of PharmacyBela, Ropar (Punjab.) 140 111,India


    Received on: 09-05-2009; Accepted on:18-07-2009

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    Author:

    Rajnibala*, Shailesh Sharma, Neelam Sharma, Ghanshyam Das Gupta

    Title:Development of Non-Bitter Zolpidem Tartrate Mouth Dissolving Tablet
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (September)
    Year:2009
    Page No: (1530-1535)
  • Experimental Methods Keywords

    Methodology:IR, DSC and XRD
    Research Materials:Zolpidem tartrate, Resinate

Keywords

Zolpidem tartrate Resinate Mouth dissolving Tablet Bitterless

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