Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000619
Title: Stability-indicating HPTLC method for estimation of dexibuprofen in pharmaceutical dosage form
Category: Pharmaceutical Chemistry
Section: Research Article
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  • Abstract

    The present work describes a stability-indicating HPTLC method for analysis of Dexibuprofen in bulk and pharmaceutical dosage form. Precoated silica gel 60 F254 plate was used as stationary phase. The separation was carried out using n-Hexane: ethylacetate: glacial acetic acid (7.5:2.5:0.2v/v/v) as mobile phase. The densitometric scanning was carried out at 225 nm. The Rf value for the drug was found to be 0.38. The linearity was obtained in the range 100-350ng /band with correlation coefficients (r2 = 0.9973). The method was validated as per ICH guidelines. Dexibuprofen was subjected to forced degradation by acid, alkali, oxidation and dry heat. The degradation products were well resolved from the pure drug with significantly different Rf values.

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    Author(s) Name:

    Sohan S. Chitlange*, Nitin Kumar and Sagar B.Wankhede

    Affiliation(s) Name:

    *Department of Pharmaceutical Chemistry, Padmashri Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchSant-Tukaram Nagar, Pimpri, Pune-411018, India.


    Received on: 20-05-2009; Accepted on:15-07-2009

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    Author:

    Sohan S. Chitlange*, Nitin Kumar and Sagar B.Wankhede

    Title:Stability-indicating HPTLC method for estimation of dexibuprofen in pharmaceutical dosage form
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (September)
    Year:2009
    Page No: (1542-1546)
  • Experimental Methods Keywords

    Methodology:HPTLC; Validation; Stability Studies
    Research Materials:Dexibuprofen

Keywords

Dexibuprofen; HPTLC; Validation; Stability Studies.

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