Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000623
Title: Formulation Optimization and Evaluation of Mometasone Furoate Cream
Category: Pharmaceutics
Section: Research Article
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    The aim of the present investigation was to develop topical cream formulations of mometasone furoate and study its permeation through rat skin. The surfactant concentration was optimized using 32 full factorial designs. The concentration of Tween 80 (X1) and concentration of Span 80 (X2) were selected as independent variables. The flux (j), cumulative amount released at 8 hours (Q8) and Enhancement ratio (ER) were selected as dependent variables. All cream formulations showed good results for different parameters like drug content, pH, viscosity, and spredibility. The penetration enhancing effect of menthol (0–10% w/w) on the percutaneous flux of mometasone furoate through the excised rat epidermis was also investigated. A marked effect of surfactants (Tween 80 Span 80) concentration on mometasone furoate permeation was observed when it was incorporated cream formulations. The values of J, ER and Q8 were strongly dependent on the independent variables. The percutaneous flux and enhancement ratio of mometasone furoate across rat epidermis was significantly increased by the addition of menthol to the cream formulations.

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    Author(s) Name:

    * R. P. Patel, R. Kamani1

    Affiliation(s) Name:

    1Department of Pharmaceutics, S.K. Patel College of Pharmaceutical Education and Research,Ganpat University, Ganpat vidyanagar, Kherva, Mehsana-Gozaria Highway, PIN-390 001, Gujarat, India.


    Received on: 20-05-2009; Accepted on:15-07-2009

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    Author:

    * R. P. Patel, R. Kamani1

    Title:Formulation Optimization and Evaluation of Mometasone Furoate Cream
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (October)
    Year:2009
    Page No: (1565-1569)
  • Experimental Methods Keywords

    Methodology:Formulation Optimization and Evaluation
    Research Materials:Mometasone furoate,

Keywords

Mometasone furoate Topical cream Factorial design In vitro skin permeation Permeation enhancer

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