Journal: Journal of Pharmacy Research

Article Id: JPRS-QA-0000634
Title: Dissolution method development and validation for combination of Cefixime Trihydrate and Erdosteine capsules
Category: Quality Assurance
Section: Research Article
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  • Abstract

    The aim of this work was to develop and validate a dissolution test for Cefixime and Erdosteine capsules using spectrophotometric method. The dissolution test conditions established were: 900 ml of 0.05 M Potassium phosphate buffer pH 7.2 adjusted with1 N NaOH as dissolution medium for 45 minutes, using a basket apparatus at a stirring rate of 100 rpm at temperature 370C. UV spectrophotometric method was developed for evaluating drug release namely absorption correction method ( 295 nm is λmax  of  CEF ,where  ERDO has practically nil absorbance,detection of ERDO  was carried out at its  λmax   237 nm) The methods was validated to meet requirements for ICH guidelines.

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    Author(s) Name:

    Madhura Vishal Dhoka*1, Vandana Tukaram Gawande1, Pranav Pramod Joshi1

    Affiliation(s) Name:

    *1 Department of Quality Assurance, A.I.S.S.M.S. College of Pharmacy, Pune University, Pune-411014, India.


    Received on: 20-05-2009; Accepted on:15-07-2009

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    Author:

    Madhura Vishal Dhoka*1, Vandana Tukaram Gawande1, Pranav Pramod Joshi1

    Title:Dissolution method development and validation for combination of Cefixime Trihydrate and Erdosteine capsules
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (November)
    Year:2009
    Page No: (1700-1704)
  • Experimental Methods Keywords

    Methodology:Dissolution method development and validation
    Research Materials:Cefixime Trihydrate

Keywords

Dissolution method; Validation ; Cefixime Trihydrate; Erdosteine

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