Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000637
Title: Formulation, Optimization and Evaluation of Mometasone Furoate Gel
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    The objective of this work was to develop the semi-solid topical gel formulations of mometasone furoate and study in vitro skin penetration through rat skin. The concentration of carbopol 940, ethanol and propylene glycol in gel formulation was optimized by Box-Behnken statistical screening design. The concentration of carbopol 940 (X1), concentration of ethanol (X2) and concentration of propylene glycol (X3) were selected as independent variables. The flux (j), total amount released at 8 hours (Q8) and enhancement Ratio (ER) were selected as dependent variables. All gel formulations showed good results for different parameters like drug content, pH, viscosity, and spredibility. A marked effect of independent variables (concentration of carbopol 940, ethanol and Propylene Glycol) on mometasone furoate permeation was observed when it was incorporated gel formulations. The values of J, ER and Q8 were strongly dependent on the independent variables.

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    Author(s) Name:

    *R. P. Patel, G. I. Patel , R. Kamani1

    Affiliation(s) Name:

    1Department of Pharmaceutics, S.K. Patel College of Pharmaceutical Education and   Research,  Ganpat University, Ganpat vidyanagar, Kherva, Mehsana-Gozaria Highway, PIN-390 001, Gujarat, India.

    Received on: 08-08-2009; Accepted on:15-09-2009

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    Author:

    *R. P. Patel, G. I. Patel , R. Kamani1

    Title:Formulation, Optimization and Evaluation of Mometasone Furoate Gel
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (November)
    Year:2009
    Page No: (1720-1724)
  • Experimental Methods Keywords

    Methodology:Formulation, Optimization and Evaluation
    Research Materials:Mometasone Furoate Gel

Keywords

Mometasone furoate Topical Gel Box-Behnken statistical screening design In vitro skin permeation.

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