Journal: Drug Invention Today

Article Id: JPRS-DFP-000064
Title: [Antibacterial and Antineoplastic Effect of Root of Euphorbia hirta L] ----------- [vol1 issue 1 2009Jan DIT]
Category: Drugs from Plants
Section: Research Article
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    This dissertation describes the antibacterial and antineoplastic effect (against Ehrlich’s Ascites Carcinoma; EAC) of methanol extract of root of Euphorbia hirta L. Methanol extract showed moderate activity against both Gram positive (Staphylococcus aureus, Bacillus subtilis, and Bacillus megaterium) and Gram negative (Escherchia coli, Shigella dysenteriae and Shigella sonnei) bacteria. In vivo the root extract resulted 45% and 54.4% Ehrlich’s Ascites Carcinoma (EAC) cell growth inhibition at the dose of 10 and 20 mg/kg body weight, respectively. The root extract also showed moderate cytotoxic effect (LC50 37.07 μg.ml-1) against Artemia salina (brine shrimp nauplii) in respect to ampicillin trihydrate (LC50 16.87 μg.ml-1).

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    Author(s) Name:

    A. K. M. Zakir Hossain Khandoker, M. Rowshanul Habib, Farjana Nikkon, Matiar Rahman, M. Rezaul Karim*

    Affiliation(s) Name:

    *Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205, Bangladesh.

    *Corresponding author.

    Dr. M. Rezaul Karim,
    Professor,
    Department of Biochemistry and Molecular Biology,
    Rajshahi University, Rajshahi-6205, Bangladesh.
    Tel.: +88-0721-750590
    Fax No. +88-0721-750064
    E-mail: rezaplazad@yahoo.com

     

    Received on: 26-08-2009; Revised on: 21-09- 2009; Accepted on:15-10-2009

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    Author:

    A. K. M. Zakir Hossain Khandoker, M. Rowshanul Habib, Farjana Nikkon, Matiar Rahman, M. Rezaul Karim*

    Title:[Antibacterial and Antineoplastic Effect of Root of Euphorbia hirta L] ----------- [vol1 issue 1 2009Jan DIT]
    Journal:Drug Invention Today
    Vol(issue):1 (January 2009)
    Year:2009
    Page No: (10-12)
  • Experimental Methods Keywords

    Methodology:Antibacterial study,Brine Shrimp Lethality Bioassay,Tumor Cells
    Research Materials:Euphorbia hirta

Keywords

Euphorbia hirta Antimicrobial Antineoplastic Ehrlich’s Ascites Carcinoma.

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