Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-0000649
Title: RP-HPLC Estimation of Entacapone in Bulk and Dosage Form
Category: Pharmaceutical Analysis
Section: Research Article
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  • Abstract

    A simple, efficient and reproducible method for the determination of entacapone in tablets has been developed using reverse phase high performance liquid chromatographic method. The elution was done using a mobile phase consisting of acetonitrile and methanol (50:50 v/v) pH adjusted to 2.75 with ortho-phosphoric acid on inertsil C18, 4.6 × 250 mm analytical column with flow rate of 1 ml/min with detection at 315 nm. An external standard calibration method was employed for quantitation. The elution time was 3.15 ± 0.02 min. The linearity was 2-12 µg/ml for entacapone.

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    Author(s) Name:

    *Lakshmi Sivasubramanian, K.S.Lakshmi and Ranga Rao Pathuri

    Affiliation(s) Name:

    Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM University, Kattankulathur – 603 203.

    Received on: 09-08-2009; Accepted on:09-11-2009

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    *Lakshmi Sivasubramanian, K.S.Lakshmi and Ranga Rao Pathuri

    Title:RP-HPLC Estimation of Entacapone in Bulk and Dosage Form
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (December)
    Page No: (1850-1851)
  • Experimental Methods Keywords

    Methodology:HPLC,quantitative analysis
    Research Materials:Entacapone


HPLC Entacapone quantitative analysis

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