Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000650
Title: In vivo anticonvulsant activity of Aegle marmelos Corr. Against pentylenetetrazole and electroconvulsive seizure in mice.
Category: Pharmacology
Section: Research Article
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    Aegle marmelos Corr. (Rutaceae) which has been widely used as an antiepileptic remedy in Indian traditional medicine. Different parts like leaves and ripe fruits have been used in the treatment of diarrhoeas, dysenteries, epilepsy and diabetes mellitus. We have taken aqueous extract isolated from the fruits of A. marmelos and studied their toxic effects. Acute, subacute and LD50 values were determined in experimental rats. Phytochemical investigations revealed the presence of flavonoids, tannins and steroids. The anticonvulsant activity of aqueous extract of the fruits of A. marmelos was examined against experimental seizures induced by Pentylenetetrazole and Electroshock in mice at a dose level of 200 and 300 mg/kg. The aqueous extract of the fruits of A. marmelos protected mice against tonic convulsions induced by maximal electroshock and especially by pentylenetetrazole in mice. Data obtained from convulsion tests were expressed as mean ± SEM and were analyzed by one-way analysis of varience (ANOVA) followed by Dunnette’s multiple comparison test.

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    Author(s) Name:

    Pandhare Ramdas.B. a*, Mohite Popat.B. a, Khanage Shantaram.Ga, Sangameswaran B b

    Affiliation(s) Name:

    a Department of Pharmacology ,MES College of Pharmacy, Sonai, Newasa, Ahmednagar-414105, Maharashtra, India.
    b Department of Pharmacognosy, Vinayaka Mission’s College of Pharmacy, Yercaud Road, Salem 636008, Tamil Nadu, India.


    Received on: 20-07-2009; Accepted on:15-10-2009

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    Author:

    Pandhare Ramdas.B. a*, Mohite Popat.B. a, Khanage Shantaram.Ga, Sangameswaran B b

    Title:In vivo anticonvulsant activity of Aegle marmelos Corr. Against pentylenetetrazole and electroconvulsive seizure in mice.
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (December)
    Year:2009
    Page No: (1852-1854)
  • Experimental Methods Keywords

    Methodology:seizure; Maximal electroshock, In vivo anticonvulsant activity
    Research Materials:Aegle marmelos

Keywords

Aegle marmelos; seizure; Maximal electroshock; Pentylenetetrazole

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