Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-0000656
Title: Studies on antioxidant and anthelmintic activity of two Streptomyces species isolated from Western Ghat soils of Agumbe, Karnataka
Category: Microbiology
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  • Abstract

    The Western Ghats are well known for their rich and unique assemblage of flora and fauna. The present study was conducted to determine antioxidant and anthelmintic potential of two actinomycetes isolates recovered from Western Ghats soils of Agumbe, Karnataka. The isolates were identified as Streptomycetes based on colony appearance, spore arrangement, biochemical and staining characteristics.The antioxidant activity of butanol extract of the culture broth of Streptomyces sp. No 1 and 2 was assessed using DPPH free radical assay and Fe+3 reducing assay. The solvent extracts of the isolates showed a dose dependent antioxidant activity. Anthelmintic activity was determined in adult Indian earthworm model. A marked dose dependent paralysis and death of worms was observed revealing anthelmintic activitiy. Among isolates, Streptomyces sp. No. 2 was found to possess marked antioxidant and anthelmintic efficacy than Streptomyces sp. No. 1. The observed activities of the isolates might be due to active principles present in the solvent extracts. Isolation and purification of the compounds possessing these potentials in the butanol extracts are to be carried.

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    Author(s) Name:

    T.R. Prashith Kekuda 1*, K.S. Shobha 2, R. Onkarappa 2

    Affiliation(s) Name:

    1 Dept. of Microbiology, S.R.N.M.N College of Applied Sciences, NES Campus, Balraj Urs Road, Shivamogga-577201, Karnataka, INDIA
    2 Dept. of Microbiology, Sahyadri Science College (Autonomous), Shivamogga-577203, Karnataka, INDIA

    *Corresponding author.
    T.R. Prashith Kekuda
    Dept. of Microbiology, S.R.N.M.N College of Applied Sciences,
    NES Campus, Balraj Urs Road, Shivamogga-577201,
    Karnataka, INDIA

    Received on: 20-09-2009; Revised on: 16-10-2009; Accepted on:15-12-2009

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    Author:

    T.R. Prashith Kekuda 1*, K.S. Shobha 2, R. Onkarappa 2

    Title:Studies on antioxidant and anthelmintic activity of two Streptomyces species isolated from Western Ghat soils of Agumbe, Karnataka
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (January)
    Year:2010
    Page No: (26-29)
  • Experimental Methods Keywords

    Methodology:Streptomyces, DPPH free radical scavenging assay, Fe+3 reducing assay
    Research Materials:Western Ghat soils of Agumbe, Karnataka

Keywords

Western Ghats Streptomyces DPPH free radical scavenging assay Fe+3 reducing assay Pheretima pasthuma

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