Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000659
Title: Self micro-emulsifying drug delivery system (SMEDDS) : Review
Category: Pharmaceutics
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  • Abstract

    Oral route has always been preferred route for formulators and has dominated over other routes of administrations. However this preferred route is limited to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Realization that the oral bioavailability of poor water soluble drugs may be enhanced when co-administered with meal rich in fat has led to increasing recent interest in the formulation of poorly water soluble drugs in lipids. Also Lipid-based drug delivery systems have gained considerable interest after the commercial success of Sandimmune NeoralTM (Cyclosporine A), Novartis Pvt. Ltd. and Fortovase (Saquinavir), Roche Laboratories Inc. with much attention focused on self micro-emulsifying drug delivery systems (SMEDDS). SMEDDS are isotropic mixtures of oil, surfactant, co-surfactant and drug with a unique ability to form fine oil in water microemulsion upon mild agitation following dilution with aqueous phase. The hypothesis behind dissolution rate enhancement with SMEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized form, and the small size of the formed droplet provides a large interfacial surface area for drug absorption. This article gives a complete overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble molecules.

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  • About the authors and Affiliations

    Author(s) Name:

    Anand U. Kyatanwar *, Kisan R. Jadhav, Vilasrao J. Kadam.

    Affiliation(s) Name:

    *Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Sector-8 Navi- Mumbai - 400614, India.

    Received on: 20-09-2009; Revised on: 16-10-2009; Accepted on:15-12-2009

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    Author:

    Anand U. Kyatanwar *, Kisan R. Jadhav, Vilasrao J. Kadam.

    Title:Self micro-emulsifying drug delivery system (SMEDDS) : Review
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (January)
    Year:2010
    Page No: (75-83)
  • Experimental Methods Keywords

    Methodology:Self micro-emulsifying drug delivery system
    Research Materials:Drugs

Keywords

SMEDDS Excipients used in SMEDDS Biopharmaceutical Aspects.

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