Journal: Drug Invention Today

Article Id: JPRS-PS-000066
Title: Sedative and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn.---- vol1 issue 1 2009 [DIT]
Category: Pharmacological Screening
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    The central nervous system (CNS) depressant and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn (FH) were investigated on various animal models including pentobarbitone sleeping time and hole-board exploratory behaviour for sedation tests, and strychnine, picrotoxin, and pentylenetetrazole-induced convulsions in mice. FH (200 and 400mg/kg, p.o.), like chlorpromazine HCl (1mg/kg, i.m.), produced a dose-dependent prolongation of pentobarbitone sleeping time and suppression of exploratory behaviour. FH (200 and 400mg/kg) produced dose-dependent and significant (P < 0.05) increases in onset to clonic and tonic convulsions, and at 400mg/kg, showed complete protection against seizures induced by strychnine and picrotoxin but not with pentylenetetrazole. Acute oral toxicity test, up to 14 days, did not produce any visible signs of toxicity. These results suggest that potencially antiepileptic compounds are present in leaf extract of FH that deserve the study of their identity and mechanism of action.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Dhanasekaran.Sivaraman* and Palayan.Muralidaran

    Affiliation(s) Name:

    *Department of Pharmacology and Toxicology,C.L.Baid Metha College of Pharmacy,Jyothi Nagar,Thoraipakkam,Chennai 97,Tamil Nadu,India.

    *Corresponding author.
    D.Sivaraman.
    No: 51, Selva vinayagar Koil Street,
    Perambur, Chennai-600011,
    Tamil nadu,India
    Tel.: + 91-9841575334
    Fax.04425522874
    E-mail: sivaramand83@gmail.com

    Received on: 14-06-2009; Revised on: 01-07- 2009; Accepted on:10-09-2009

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    9 View More
  • How to Cite my Article.

    Author:

    Dhanasekaran.Sivaraman* and Palayan.Muralidaran

    Title:Sedative and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn.---- vol1 issue 1 2009 [DIT]
    Journal:Drug Invention Today
    Vol(issue):1 (January 2009)
    Year:2009
    Page No: (23-27)
  • Experimental Methods Keywords

    Methodology:Pentobarbitone induced sleeping time.,Strychnine induced seizures, Picrotoxin-induced seizures,Pentylenetetrazole (PTZ)-induced seizures
    Research Materials:Ficus hispida Linn

Keywords

Ficus hispida Linn; Anticonvulsants; Phenobarbital; Strychnine; Picrotoxin; Pentylenetetrazole.

Our Services

Most Downloaded List