Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000663
Title: Solubility and Dissolution Enhancement: An overview
Category: Pharmaceutics
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  • Abstract

    Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility have low dissolution rates and hence suffer from oral bioavailability problems. The poor solubility and poor dissolution rate of poorly water soluble drugs in the aqueous gastro intestinal fluids often cause insufficient bioavailability. Other in-vivo consequences due to poor aqueous solubility include increased chances of food effect, more frequent incomplete drug release from the dosage form and higher inter-patient variability.Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active substance is a key property. As it governs dissolution, absorption and thus the in vivo efficacy. The present review deals in detail about the different techniques used for the improvement of the solubility and dissolution rate of poorly water soluble drugs include, Inclusion complexation with cyclodextrins, Size reduction technology, Functional polymer technology and Solid dispersions etc.

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    Author(s) Name:

    V.Rajesh Babu*1, S.H.Areefulla1, V.Mallikarjun2

    Affiliation(s) Name:

    1Department of Pharmaceutics, MESCO College of Pharmacy, Hyderabad, A.P, India-500006
    2Department of Pharmaceutics, SR College of Pharmacy, Warangal, A.P, India-506009

    Received on: 20-09-2009; Revised on: 16-10-2009; Accepted on:15-12-2009

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    Author:

    V.Rajesh Babu*1, S.H.Areefulla1, V.Mallikarjun2

    Title:Solubility and Dissolution Enhancement: An overview
    Journal:Journal of Pharmacy Research
    Vol(issue):3(1)
    Year:2010
    Page No: (141-145)
  • Experimental Methods Keywords

    Methodology:Solubility, Dissolution, Cosolvent, Solid dispersions
    Research Materials:Drugs

Keywords

Solubility Dissolution Cosolvent Solid dispersions and Cyclodextrins.

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