Journal: Drug Invention Today

Article Id: JPRS-PS-000067
Title: Protective effect of ethanolic extract of stem bark of Ailanthus excelsa Roxb. against CCl4 induced hepatotoxicity in rats------------VOL1 ISSUE 1,2009,[DIT]
Category: Pharmacological Screening
Section: Research Article
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    The present study was carried out to evaluate the hepatoprotective effect of ethanolic extract of stem bark of Ailanthus excelsa, Roxb. in Wister albino rats by inducing liver damage by carbon tetra chloride (CCl4). The ethanolic extract at a oral dose of 200mg/kg exhibited significant (p<0.001) hepatoprotective effect by lowering serum enzyme levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TB). These observations were supplemented by histopathological examination of liver section. Silymarin was used as positive control.

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    Author(s) Name:

    G. Prakash Yoganandam1*, K.Periyanayagam2 and K.Ilango3.

    Affiliation(s) Name:

    1Department of Pharmacognosy,SRM College of Pharmacy,SRM University, Kattankulathur – 603 203,Kancheepuram Dist. Tamil Nadu, India.
    2Department of Pharmacognosy,Madurai Medical College, Madurai-625020. Tamil Nadu, India.
    3Department of Pharmaceutical Chemistry,SRM College of Pharmacy, SRM University, Kattankulathur – 603 203,Kancheepuram Dist. Tamil Nadu,India.

    *Corresponding author.
    G.Prakash Yoganandam,
    Department of Pharmacognosy,
    SRM College of Pharmacy,
    SRM University, Kattankulathur-603 203.
    Tel.: + 91-9962016232
    Fax:+91-44-27455717
    E-mail: glmsp2003@yahoo.co.in

    Received on: 14-06-2009; Revised on: 27-07- 2009; Accepted on:09-09-2009

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    Author:

    G. Prakash Yoganandam1*, K.Periyanayagam2 and K.Ilango3.

    Title:Protective effect of ethanolic extract of stem bark of Ailanthus excelsa Roxb. against CCl4 induced hepatotoxicity in rats------------VOL1 ISSUE 1,2009,[DIT]
    Journal:Drug Invention Today
    Vol(issue):1 (January 2009)
    Year:2009
    Page No: (28-31)
  • Experimental Methods Keywords

    Methodology:Effect on serum enzymatic activity,CCl4.
    Research Materials:Ailanthus excelsa

Keywords

Ailanthus excelsa Simaroubaceae Hepatoprotective CCl4.

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