Journal: Journal of Pharmacy Research
Title: Lipophilicity Measurement Through Newer Techniques
Category: Pharmaceutics
Section: Review Article
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Abstract
This review describes lipophilicity parameters used in drug designing. Lipophilicity is an important parameter related to drug properties, such as drug absorption, plasma protein binding, hydrophobic drug-receptor interactions and partly the pharmacokinetic behaviour and toxicological properties and recognized today as one of the major challenges in oral delivery of new drug substances. The tremendous knowledge accumulated on biological factors and as well as on the physicochemical characteristics of the drug substances lipophilcity affecting oral bioavailability. The new methods (RP-HPLC, RP-TLC, Liposomes partitioning, IAM Chromatography, Electrokinetic approaches) have been discussed to measure the lipophilicity of xenobiotics and to overcome the problems with existing methods.
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About the authors and Affiliations
Author(s) Name: *Bhawana Sethia, Mohit Sonib, Sandeep Kumarb, G.D. Guptab, Santosh Mishraa and Ranjit Singha.
Affiliation(s) Name: *a School of Pharmaceutical Sciences, Shobhit University, Meerut
b Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela, Ropar, (Punjab) 140111 INDIA*Corresponding author.
Bhawana Sethi
Research Scholar
School of Pharmaceutical Sciences
Shobhit University, Meerut,Uttar Pradesh, India
Received on: 20-09-2009; Revised on: 17-17-2009; Accepted on:15-01-2010-
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How to Cite my Article.
Author: *Bhawana Sethia, Mohit Sonib, Sandeep Kumarb, G.D. Guptab, Santosh Mishraa and Ranjit Singha.
Title: Lipophilicity Measurement Through Newer Techniques Journal: Journal of Pharmacy Research Vol(issue): 3 (February) Year: 2010 Page No: (345-351) -
Experimental Methods Keywords
Methodology: RP-HPLC, RP-TLC, Liposomes partitioning, IAM Chromatography, Electrokinetic approaches. Research Materials: Lipophilicity
Keywords
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