Journal: Journal of Pharmacy Research
Title: Lipophilicity Measurement Through Newer Techniques
Category: Pharmaceutics
Section: Review Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
This review describes lipophilicity parameters used in drug designing. Lipophilicity is an important parameter related to drug properties, such as drug absorption, plasma protein binding, hydrophobic drug-receptor interactions and partly the pharmacokinetic behaviour and toxicological properties and recognized today as one of the major challenges in oral delivery of new drug substances. The tremendous knowledge accumulated on biological factors and as well as on the physicochemical characteristics of the drug substances lipophilcity affecting oral bioavailability. The new methods (RP-HPLC, RP-TLC, Liposomes partitioning, IAM Chromatography, Electrokinetic approaches) have been discussed to measure the lipophilicity of xenobiotics and to overcome the problems with existing methods.
-
Abstract Audio
About the authors and Affiliations
Author(s) Name: *Bhawana Sethia, Mohit Sonib, Sandeep Kumarb, G.D. Guptab, Santosh Mishraa and Ranjit Singha.
Affiliation(s) Name: *a School of Pharmaceutical Sciences, Shobhit University, Meerut
b Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela, Ropar, (Punjab) 140111 INDIA*Corresponding author.
Bhawana Sethi
Research Scholar
School of Pharmaceutical Sciences
Shobhit University, Meerut,Uttar Pradesh, India
Received on: 20-09-2009; Revised on: 17-17-2009; Accepted on:15-01-2010-
View Article File in pdf format.
Article File
-
View Article Citation Here.
9 View More -
How to Cite my Article.
Author: *Bhawana Sethia, Mohit Sonib, Sandeep Kumarb, G.D. Guptab, Santosh Mishraa and Ranjit Singha.
Title: Lipophilicity Measurement Through Newer Techniques Journal: Journal of Pharmacy Research Vol(issue): 3 (February) Year: 2010 Page No: (345-351) -
Experimental Methods Keywords
Methodology: RP-HPLC, RP-TLC, Liposomes partitioning, IAM Chromatography, Electrokinetic approaches. Research Materials: Lipophilicity
Keywords
Our Services
- Pharmacognostic standardization and high-performance thin-layer chromatography fingerprint profile of Lagenaria siceraria (Molina) Standl. fruits
- Mucoadhesive oral in situ gel of itraconazole using pH-sensitive polymers: Preparation, and in vitro characterization, release and rheology study
- Antibacterial activity of different endodontic sealers: An in vitro evaluation
- Effectiveness of good behavior game on oral health among children - A randomized trial
- Effect of music on academic performance of college students
- Medicinal uses of banana (Musa paradisiaca)
- Biodegradable plastic production from corn starch
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- The role of toponymic objects in the system of settlement and reconstruction of landscapes in the Pre-Volga Region of the Republic of Tatarstan
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Estimation of Tizanidine HCl by UV-Spectrophotometric Method
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Effects of lupeol on insulin receptor and glucose transporter-4 in cardiac tissue of Type-2 diabetic rats
- Simultaneous Spectrophotometric Estimation of Paracetamol and Aceclofenac in Combined Tablet Formulations using Hydrotropic Solubilization Technique
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Formulation and Evaluation of Sildenafil Citrate Fast Dissolving Tablets Using Crospovidone and Croscarmellose Sodium Superdisintegrants
- Formulation and evaluation of solid dispersions of valsartan for dissolution rate enhancement
- Ethosomes: A novel tool for drug delivery through the skin
- Validation of Uv Spectrophotometric method for estimation of Levocetirizine Dihydrochloride in bulk and pharmaceutical formulation
- In silico and in vivo approach to identify the antidiabetic activity of lupeol
- Fomulation and Evaluation of Taste Masked Spherical Agglomerates of Telmisartan
- Assortment of vital nutrients for enhancement of Cyclodextrin glycosyltransferase produced by Bacillus amyloliquefaciens KST5: A Plackett-Burman design approach
- In vitro antibacterial activity of essential oils of selected herbals against isolates from HIV/AIDS patients
- Comparative Study of Ionotropic Gelation Technique To Entrap Diltiazem HCl In Mucoadhesive Microparticulate System.
- Aspergillus Derived Silver Nano Particles as a Potent Antibacterial Agent and Identification of Linked Proteins
- Preparation and Characterization of Pharmaceutical Grade Chitosan And Hydrated Chitosan Gums for Topical Preparations
- Novel Controlled Gastroretentive Drug Delivery Systems: A Review
- Antiulcer activity of aqueous suspension of Saraca indica flower against gastric ulcers in albino rats
- A Case Study on Zinc Phosphide Poisoning in Tamil Nadu