Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000679
Title: Lipophilicity Measurement Through Newer Techniques
Category: Pharmaceutics
Section: Review Article
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  • Abstract

    This review describes lipophilicity parameters used in drug designing. Lipophilicity is an important parameter related to drug properties, such as drug absorption, plasma protein binding, hydrophobic drug-receptor interactions and partly the pharmacokinetic behaviour and toxicological properties and recognized today as one of the major challenges in oral delivery of new drug substances. The tremendous knowledge accumulated on biological factors and as well as on the physicochemical characteristics of the drug substances lipophilcity affecting oral bioavailability. The new methods (RP-HPLC, RP-TLC, Liposomes partitioning, IAM Chromatography, Electrokinetic approaches) have been discussed to measure the lipophilicity of xenobiotics and to overcome the problems with existing methods.

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  • About the authors and Affiliations

    Author(s) Name:

    *Bhawana Sethia, Mohit Sonib, Sandeep Kumarb, G.D. Guptab, Santosh Mishraa and Ranjit Singha.

    Affiliation(s) Name:

    *a School of Pharmaceutical Sciences, Shobhit University, Meerut
    b Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela, Ropar, (Punjab) 140111 INDIA

    *Corresponding author.
    Bhawana Sethi
    Research Scholar
    School of Pharmaceutical Sciences
    Shobhit University, Meerut,Uttar Pradesh, India

    Received on: 20-09-2009; Revised on: 17-17-2009; Accepted on:15-01-2010

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    Author:

    *Bhawana Sethia, Mohit Sonib, Sandeep Kumarb, G.D. Guptab, Santosh Mishraa and Ranjit Singha.
    Title:Lipophilicity Measurement Through Newer Techniques
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (February)
    Year:2010
    Page No: (345-351)

  • Experimental Methods Keywords

    Methodology:RP-HPLC, RP-TLC, Liposomes partitioning, IAM Chromatography, Electrokinetic approaches.
    Research Materials: Lipophilicity

Keywords

Lipophilicity RP-HPLC RP-TLC Liposomes partitioning IAM Chromatography Electrokinetic approaches.

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