Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00007
Title: Optimization and In Vitro Evaluation of Floating Tablets of Atenolol
Category: Pharmaceutics
Section: Research Article
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    The main aim of this study was to optimize and evaluate the floating tablets of atenolol that prolongs the gastric residence time. Semisynthetic polymers, HPMC K4M, HPMC K100M and natural polymer, Xanthan gum were used as release retarding agents. Sodium bicarbonate was used as a gas-generating agent. Dicalcium phosphate was  used as a channeling agent. The floating matrix tablets of Atenolol were prepared by direct compression method. The  concentration of polymers and a gas-generating agent was optimized to get the controlled release of atenolol for 8h. The prepared tablets were evaluated for physicochemical parameters and found to be within range. A significant difference in drug release at 0.5, 1, 4 and 8 h (p < 0.0001) was observed. The floating lag time of all the formulations was within the prescribed limit (< 10 min.) Release pattern of Atenolol was fitted to different models based on coefficient of correlation (R). All the formulations showed good matrix integrity. All the formulations retarded the release of drug for 8 h. Based on the diffusion exponent (n) value, drug release was found to be diffusion controlled. The swelling studies of all the formulations showed that formulations containing Xanthan gum has higher swelling indices than HPMC K100M and HPMC K4M. Further it was observed that the formulations, which are having higher swelling indices, retarded the release of drugs than those having low swelling indices.

    Cite this article as : Vijay Daulatrao Havaldar, Ajit Shankarrao Kulkarni , Remeth Jacky Dias, Kailas Krishnat Mali.,Optimization and In Vitro Evaluation of Floating Tablets of Atenolol, Journal of Pharmacy Research, Vol.1.Issue 1. July-September 2008,73-78

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    Author(s) Name:

    Vijay Daulatrao Havaldar1 *, Ajit Shankarrao Kulkarni 1, Remeth Jacky Dias1, Kailas Krishnat Mali.1
    1Satara College of Pharmacy, Plot.No.1539, New Additional M.I.D.C, Degaon, Satara, 415004, M.S. India

    Affiliation(s) Name:

    For correspondance: Vijay Daulatrao Havaldar, Satara College of Pharmacy, Plot.No.1539, 
    New Additional M.I.D.C, Degaon, Satara, M.S. India PIN 415004 
    E mail: vdh2006@rediffmail.com 


    Received on: 10-06-2008; Accepted on :14-07-2008

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    Author:

    Vijay Daulatrao Havaldar1 *, Ajit Shankarrao Kulkarni 1, Remeth Jacky Dias1, Kailas Krishnat Mali.1
    1Satara College of Pharmacy, Plot.No.1539, New Additional M.I.D.C, Degaon, Satara, 415004, M.S. India

    Title:Optimization and In Vitro Evaluation of Floating Tablets of Atenolol
    Journal:Journal of Pharmacy Research
    Vol(issue):1 (July-September 2008)
    Year:2008
    Page No: (73-78)
  • Experimental Methods Keywords

    Methodology:Optimization and In Vitro Evaluation
    Research Materials:Atenolol

Keywords

Floating Atenolol Swelling index HPMC.

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