Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000702
Title: Report on pharmaceutical approaches to colon targeted drug delivery systems
Category: Pharmaceutics
Section: Review Article
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    Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides. The various strategies for targeting orally administered drugs to the colon include covalent linkage of a drug with a carrier, coating with pH-sensitive polymers, formulation of timed released systems, exploitation of carriers that are degraded specifically by colonic bacteria, bioadhesive systems and osmotic controlled drug delivery systems. The approach that is based on the formation of prodrug involves covalent linkage between drug and carrier. The presence of azo reductase enzymes play pivotal role in the release of drug from azo bond prodrugs while glycosidase activity of the colonic microflora is responsible for liberation of drugs from glycosidic prodrugs. Natural polysaccharides have been used as tools to deliver the drugs specifically to the colon. Formulation coated with enteric polymers releases drug when pH move towards alkaline range while as the multicoated formulation passes the stomach, the drug is released after a lag time of 3-5 h that is equivalent to small intestinal transit time. Drug coated with a bioadhesive polymer that selectively provides adhesion to the colonic mucosa may release drug in the colon. The review is aimed at understanding pharmaceutical approaches to colon targeted drug delivery systems for better therapeutic action without compromising on drug degradation or its low bioavailability.

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    Author(s) Name:

    Manoj Kumar*, Akabar Ali , Prashant Kaldhone, Abhay Shirode, Vilasrao. J. Kadam.

    Affiliation(s) Name:

    *Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Sector-8 Navi- Mumbai - 400614, India.

    *Corresponding author. 
    Manoj Kumar*, 
    M.Pharmacy ( Pharmaceutics) 
    Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, 
    Navi Mumbai-400614


    Received on: 23-12-2009; Revised on: 04-01-2010; Accepted on:06-02-2010

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    Author:

    Manoj Kumar*, Akabar Ali , Prashant Kaldhone, Abhay Shirode, Vilasrao. J. Kadam.

    Title:Report on pharmaceutical approaches to colon targeted drug delivery systems
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (March)
    Year:2010
    Page No: (470-473)
  • Experimental Methods Keywords

    Methodology:Colonic drug delivery
    Research Materials:pH-sensitive polymers

Keywords

pH-sensitive polymers Timed released systems Bioadhesive systems Osmotic controlled drug delivery systems.

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