Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000708
Title: Synthesis and antimicrobial activity of some novel ciprofloxacin analogues
Category: Pharmaceutical Chemistry
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    From the cyclisation of potassium dithiocarbazinate with hydrazine hydrate in water, 4-(amino)-5-phenyl - 4H-1, 2, 4-triazole- 3- thiol belonging to the 1,2,4- triazole derivative have been prepared. The different aromatic aldehydes such as benzaldehyde, 2-hydroxy benzaldehyde, 2,4-dichloro benzaldehyde, 3-methoxy 4-hydroxy benzaldehyde, 4-dimethyl amino benzaldehyde and furfuraldehyde have been attached to the triazole through the Schiff reaction to give different Schiff bases. Ciprofloxacin have been incorporated to the new series of Schiff bases of 1,2,4- triazole via Mannich reaction. The new compounds have been evaluated in vitro for their antimicrobial activity against B.subtilis, K.Pneumoniae, and P.aeruginosa. All the compounds showed in vitro gram positive and gram negative activity generally comparable or superior to that of reference ciprofloxacin.

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    Author(s) Name:

    S Jubie*, Pranabesh Sikdar, R Kalirajan, B Gowramma, S Gomathy, S Sankar & K Elango.

    Affiliation(s) Name:

    1Department of Pharmaceutical Chemistry, J.S.S. University, off campus, Ooty-643 001.2500 26.12.2009.

    *Corresponding author.
    S. Jubie,
    Department of Pharmaceutical Chemistry,
    J. S. S. College of Pharmacy,
    Rockland, Ooty-643 001,India


    Received on: 20-11-2009; Revised on: 06-12-2009; Accepted on:18-02-2010

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    Author:

    S Jubie*, Pranabesh Sikdar, R Kalirajan, B Gowramma, S Gomathy, S Sankar & K Elango.

    Title:Synthesis and antimicrobial activity of some novel ciprofloxacin analogues
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (March)
    Year:2010
    Page No: (511-513)
  • Experimental Methods Keywords

    Methodology:Synthesis and antimicrobial activity
    Research Materials:some novel ciprofloxacin analogues

Keywords

Ciprofloxacin Triazole Schiff bases Mannich bases antimicrobial.

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