Journal: Journal of Pharmacy Research
Title: Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
The aim of this research was to investigate antidiabetic activity of Costus igneus (also known as insulin plant) leaves extracts in alloxan induced diabetic albino rats. A comparison was made between the action of Costus igneus extract and a known antidiabetic drug glibenclamide (600 µg/kg body wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. Ethanolic extracts of Costus igneus were obtained by simple maceration method & were subjected to standardization by phytochemical screening methods. Preliminary phytochemical investigations showed the presence of alkaloids and steroids in ethanolic extract. Dose selection was made on the basis of acute oral toxicity study (50mg to 5000 mg/kg body weight) as per OECD guidelines. Costus igneus ethanolic extract showed significant (P<0.001) antidiabetic activity. These extracts also prevented body weight loss in diabetic rats. We are the first to report Costus igneus leaves pharmacognostic, phytochemical investigations and its antidiabetic activity in OGTT and alloxan induced model.
-
Abstract Audio
About the authors and Affiliations
Author(s) Name: Bhat Vishnu*, Asuti Naveen, Kamat Akshay, Sikarwar Mukesh. S., Patil M. B.
Affiliation(s) Name: *Department of Pharmacognosy and Phytochemistry, K.L.E’S College of Pharmacy, Ankola-581314, Uttar Kannada, Karnataka, India,
*Corresponding author.
Bhat Vishnu
Department of Pharmacognosy and Phytochemistry,
K.L.E’S College of Pharmacy, Ankola-581314,
Uttar Kannada, Karnataka, India,
Received on: 20-10-2009; Revised on: 19-12-2009; Accepted on:22-02-2010-
View Article File in pdf format.
Article File
-
View Article Citation Here.
18 View More -
How to Cite my Article.
Author: Bhat Vishnu*, Asuti Naveen, Kamat Akshay, Sikarwar Mukesh. S., Patil M. B.
Title: Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats Journal: Journal of Pharmacy Research Vol(issue): 3 (March) Year: 2010 Page No: (608-611) -
Experimental Methods Keywords
Methodology: Antidiabetic activity Research Materials: Costus igneus
Keywords
Our Services
- Ashwini Shenai, Dhanraj Ganapathy*, Revathy Gounder
- Orally Disintegrating Tablets: A Review
- Application of nanotechnology for Ayurvedic drugs and formulations
- The effect of red betel leaves (Piper crocatum Ruiz and Pav.) on blood sugar and insulin expression levels in rat (Rattus norvegicus domesticus) models of diabetes mellitus
- Antimicrobial activity of ß-asarone from Acorus calamus leaves
- Phytosomes: a potential phyto-phospholipid carriers for herbal drug delivery
- Anatomical observation and morphometric analysis of impressions of dural venous sinuses in dry human occipital bone
- Effect of Kapalbhati Pranayama in the blood sugar level in diabetic patients
- Excessive usage of headphones among college students and their effects
- Knowledge, attitude, and awareness regarding needlestick injury among dental practitioners in Chennai
- Evaluation of skin corrosive property of ethanolic leaf extract of Acyranthus aspera by in vitro Transcutaneous Electrical Resistance Test and Human skin Model Test.
- Anti-pyretic activity of the ethanolic extract of the powdered leaves of Murraya Koenigii (L.) Spreng
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Effect of music on academic performance of college students
- Development and Evaluation of Polysaccharide Based Matrix Tablets of Celecoxib for Colonic Delivery
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Characterization and formulation of prednisolone acetate reconstituted suspension
- Use of Canna indica Flower Extract As A Natural Indicator In Acid Base Titration
- Optimization of Irbesartan tablet formulation by 22 factorial design
- Evaluation of acute and subacute toxicity of aqueous extracts from Marrubium vulgare L in rodents
- Triazolo aspirins inhibit proliferation of C6 glioma cell lines in vitro
- Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
- Wound healing activity of the leaves of Tribulus terrestris (linn) aqueous extract in rats
- Insights into Polymers: Film Formers in Mouth Dissolving Films
- Abutment selection in fixed partial denture - A review
- Dose dependent antioxidant activity of fresh juice of leaves of Coriandrum sativum
- Abrus precatorius Linnaeus: A Phytopharmacological Review
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Simultaneous estimation of rizatriptan, sumatriptan and zolmitriptan by RP-HPLC method in bulk
- Docetaxel-loaded chitosan nanoparticles to enhance the chemotherapeutic efficacy in lung cancer