Journal: Journal of Pharmacy Research
Title: Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
The aim of this research was to investigate antidiabetic activity of Costus igneus (also known as insulin plant) leaves extracts in alloxan induced diabetic albino rats. A comparison was made between the action of Costus igneus extract and a known antidiabetic drug glibenclamide (600 µg/kg body wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. Ethanolic extracts of Costus igneus were obtained by simple maceration method & were subjected to standardization by phytochemical screening methods. Preliminary phytochemical investigations showed the presence of alkaloids and steroids in ethanolic extract. Dose selection was made on the basis of acute oral toxicity study (50mg to 5000 mg/kg body weight) as per OECD guidelines. Costus igneus ethanolic extract showed significant (P<0.001) antidiabetic activity. These extracts also prevented body weight loss in diabetic rats. We are the first to report Costus igneus leaves pharmacognostic, phytochemical investigations and its antidiabetic activity in OGTT and alloxan induced model.
-
Abstract Audio
About the authors and Affiliations
Author(s) Name: Bhat Vishnu*, Asuti Naveen, Kamat Akshay, Sikarwar Mukesh. S., Patil M. B.
Affiliation(s) Name: *Department of Pharmacognosy and Phytochemistry, K.L.E’S College of Pharmacy, Ankola-581314, Uttar Kannada, Karnataka, India,
*Corresponding author.
Bhat Vishnu
Department of Pharmacognosy and Phytochemistry,
K.L.E’S College of Pharmacy, Ankola-581314,
Uttar Kannada, Karnataka, India,
Received on: 20-10-2009; Revised on: 19-12-2009; Accepted on:22-02-2010-
View Article File in pdf format.
Article File
-
View Article Citation Here.
18 View More -
How to Cite my Article.
Author: Bhat Vishnu*, Asuti Naveen, Kamat Akshay, Sikarwar Mukesh. S., Patil M. B.
Title: Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats Journal: Journal of Pharmacy Research Vol(issue): 3 (March) Year: 2010 Page No: (608-611) -
Experimental Methods Keywords
Methodology: Antidiabetic activity Research Materials: Costus igneus
Keywords
Our Services
- Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats
- Solubility and Dissolution Enhancement: An overview
- In vitro antioxidant and ptp inhibitory activity of methanolic extract of Anogeissus acuminata leaf and bark.
- A review on Calotropis procera Linn and its Ethnobotany, Phytochemical, Pharmacological profile
- Antimicrobial activity and phytochemical screening of five wild plants against Escherichia coli, Bacillus subtilis and Staphylococcus aureus
- A review on quality by design approach for analytical method development
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Evaluation of Phenolic Content and Antioxidant Capacity of leaf extract from Phoenix Dactylifera L obtained by different pH of aqueous extraction
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats
- Biological synthesis of silver nanoparticles using aqueous leaf extract of Capparis decidua (FORSK.) EDGEW: A better alternative
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Study of health related quality of life in rheumatoid arthritis patients
- Prescribing Patterns of antihypertensive drugs in a South Indian tertiary care hospital
- In vitro antioxidant, anti-inflammatory and anticholinesterase activities of Rumex vesicarius L
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
- Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
- In vitro anti-Candida activity of Calotropis gigantea.
- Pharmacognostic, Phytochemical & Quantitative Investigation of Saraca asoca leaves
- Anti ulcer activity of Naravelia zeylanica leaves extract
- Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study.
- Effects of Osmolytes on The Structural Stability of Bovine Trypsin: A Brief Review
- Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents
- Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent
- In vitro Antioxidant Activity from Leaves of Oroxylum indicum (L.) Vent. -A North Indian Highly Threatened and Vulnerable Medicinal Plant
- Assessment of Pharmacognostical Characters of Leaves of Tephrosia Purpurea Linn
- Genome of Acinetobacter baumannii Carries Multi Drug Resistance Genes
- Triazole analogues as novel antioxidants: In vitro bioassay and molecular modeling studies
- Anticonvulsant And Antioxidant Actions Of Some Dibenzo-a-Pyrone Derivatives In Pentylene –Induced Kindling Model In Mice