Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000730
Title: Novel approach to formulate â-cyclodextrin complexed mouth dissolving tablet of Metronidazole and its in-vitro evaluation
Category: Pharmaceutics
Section: Editorial
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    Patients with oro-dental diseases like gingivitis, periodontal disease, bleeding gums and oral infections are at increased risk of dysphasia and leads to patient noncompliance. In such conditions it is also necessary to give rapid action and avoidance of first pass metabolism which is made possible by formulating Mouth dissolving tablets of Metronidazole. The mouth dissolving tablets of metronidazole was prepared by direct compression technique. Bitter taste of drug is successfully masked by b-cyclodextrin (b-CD) complex and is also useful to enhance the solubility which was confirm by phase solubility analysis with constant value 107.52 M-1 .FT-IR spectroscopy study confirm the formation of inclusion complex , and compatibility of polymers Metronidazole was also confirmed by FTIR Spectroscopy studies. The tablets showed good weight uniformity (RSD< 1%), The Drug content uniformity of the Tablet was found to comply with the official specification, tablet Hardness varied from 3.5 ±0.1 to 4.0 ± 0.4 and tablets passed the friability test. The tablet formulation which contain SSG alone and combination of SSG- Bamboomanna showed good result for wetting time, in-vitro dispersion Time, disintegration time, mouth feel and dissolution studies.

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    Author(s) Name:

    *Mohire N.C,Yadav A.V.

    Affiliation(s) Name:

    *Research scholar,Department of Pharmacy,Government College of Pharmacy, Karad.Tal-Karad, Dist-Satara, Maharashtra, India
    Principal & Professor in Pharmaceutics,KIMS University,Krishna Institute of Pharmacy, Karad.Tal-Karad, Dist-Satara, Maharashtra, India

    *Corresponding author.
    Mr. Mohire N.C.
    Research scholar, Department of Pharmacy,
    Government College of Pharmacy, Karad.
    Tal-Karad, Dist-Satara, Maharashtra, India


    Received on: 20-11-2009; Revised on: 16-12-2009; Accepted on:15-02-2010

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    Author:

    *Mohire N.C,Yadav A.V.

    Title:Novel approach to formulate â-cyclodextrin complexed mouth dissolving tablet of Metronidazole and its in-vitro evaluation
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (March)
    Year:2010
    Page No: (662-667)
  • Experimental Methods Keywords

    Methodology:Novel approach to formulate â-cyclodextrin complexed, FT-IR spectroscopy study
    Research Materials:Metronidazole

Keywords

Metronidazole mouth dissolving tablets beta-cyclodextrin Chitosan sodium starch glycolate

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