Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-000074
Title: Synthesis and preliminary evaluation of some 2-amino-n’-[substituted]-4,5,6,7- tetrahydro-1-benzothiophene-3-carbohydrazide as antimicrobial agents.
Category: Pharmaceutical Chemistry
Section: Research Article
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  • Abstract

    A new series of 2-amino-N’-[substituted]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbohydrazide 2(a-i) were synthesized using appropriate synthetic route. The entire test compounds were assayed in vitro for antibacterial activity against two different strains of Gram-positive (S. aureus, B. subtilis and S. faecalis), Gram-negative (E. coli, P. aeruginosa and S. typhi) bacteria and the antifungal activity against (C. albicans, A. flavus and A. niger) fungi. The minimum inhibitory concentration (MIC) was determined for test compounds and for reference standards. The test compounds showed significant antibacterial and antifungal activity against the microbial strains used, when tested in vitro.

    Cite this article as:V. A.Jagtap and Y. S. Agasimundin,Synthesis and preliminary evaluation of some 2-amino-n’-[substituted]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbohydrazide as antimicrobial agents. Journal of Pharmacy Research 2015,9(1),10-14.

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    Author(s) Name:

    * V. A. Jagtap and Y. S. Agasimundin 1

    Affiliation(s) Name:

    *,Assistant Professor, Dept. of Pharmaceutical Chemistry, Smt. S. S. Patil College of Pharmacy, Chopda – 425 107, Maharashtra, India.
    1Professor, PG Dept. of Pharmaceutical Chemistry, S. C. S. College of Pharmacy, Harapanahalli-583 131, Karnataka, India.

    *Corresponding author.
    Prof. Jagtap Vijay A.,
    Asst. Professor,
    Dept. of Pharmaceutical Chemistry,
    Smt. S. S. Patil College of Pharmacy,
    Chopda – 425 107
    Dist: Jalgaon (Maharashtra State),Idnia.

    E-mail: jagtap.va@gmail.com



    Received on:20-11-2014; Revised on: 19-12-2014; Accepted on:06-01-2015

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    Author:

    * V. A. Jagtap and Y. S. Agasimundin 1

    Title:Synthesis and preliminary evaluation of some 2-amino-n’-[substituted]-4,5,6,7- tetrahydro-1-benzothiophene-3-carbohydrazide as antimicrobial agents.
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (January )
    Year:2015
    Page No: (10-14)
  • Experimental Methods Keywords

    Methodology:synthesis, Antimicrobial activity
    Research Materials:A new series of 2-amino-N’-[substituted]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbohydrazide

Keywords

Tetrahydrobenzothiophene; Carbohydrazide; Antimicrobial activity.

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