Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000751
Title: Formulation and evaluation of In-Situ gel of metoprolol tartrate for nasal delivery
Category: Pharmaceutics
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    The objective of present investigation was to develop a mucoadhesive in-situ gel; formulation was developed with aim to reduce the mucociliary clearance by using mucoadhesive polymer in gel, thereby increasing the contact of formulation with nasal mucosa and hence improving the absorption of drug. The in-situ gelation was achieved by the use of pluronic F127, which exhibit thermoreversible gelation property. The formulation additives are having effect on thermodynamic of phase transitions at gelation (T1) and gel melting (T2) temperature. Result revealed that addition of mucoadhesive polymer Carbopol934 has decreased T1 whereas addition of PEG400 increased T1 and also PEG400 increased in- vitro drug release. In- vitro drug release shows that with increasing carbopol concentration increases viscosity of formulation and influences the diffusion of drug particle while addition of PEG 400 enhances in vitro drug release.

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    Author(s) Name:

    Varsha Gaikwad

    Affiliation(s) Name:

    Dept.of Pharmaceutics, Y.B.Chavan college of Pharmacy, Raffiq Zakeria marg,Rauza Bagh,Aurangabad.431 001.

    *Corresponding author.
    Varsha Gaikwad
    Dept.of Pharmaceutics, Y.B.Chavan college of Pharmacy, Raffiq Zakeria marg,Rauza Bagh,Aurangabad.431 001.


    Received on: 21-10-2009; Revised on: 17-12-2009; Accepted on:15-02-2010

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    Author:

    Varsha Gaikwad

    Title:Formulation and evaluation of In-Situ gel of metoprolol tartrate for nasal delivery
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (April)
    Year:2010
    Page No: (788-793)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials: Metoprolol tartrate

Keywords

Metoprolol tartrate nasal delivery in-situ gel pluronic F127.

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