Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000765
Title: Suitability of Factorial Design in Determining the Processing Factors Affecting Entrapment Efficiency of Albumin Microspheres
Category: Pharmaceutics
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    Introduction: A trend in NSAID development has been to formulate them into sustained release microspheres to improve therapeutic efficacy and to reduce the severity of upper gastro intestinal side effects. Many processing variables can influence the characteristics of the resultant albumin microspheres. Objective: The objective of the present study was to study the effect of some selected process variables (drug/albumin ratio, amount of glutaraldehyde, and duration of cross-linking time) on the encapsulation efficiency, by applying 3-level full factorial design analysis, accounting for percent drug entrapment as dependant variable. Methods: Sustained-release formulations of ketorolac tromethamine loaded albumin microspheres were prepared by chemical cross-linking method. F-statistic was applied to reduce polynomial equation by neglecting non-significant (P>0.05) terms.The coefficient value for independent variable, drug/albumin ratio, was found to be maximum (19.33) and hence this variable was considered to be a major contributing variable for percent drug entrapment. Response surface plots clearly showed optimal drug/albumin ratio, amount of glutaraldehyde and duration of cross-linking. The conformity of the established equation was checked by preparing three batches of microspheres thrice, taking values of the independent variables from the contour plots for prefixed value of percent drug entrapment. Conclusion: Findings established the role of the statistical design in predicting the values of independent variables for preparation of microspheres having predetermined percent drug entrapment.

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    Author(s) Name:

    Sam T Mathew1*, Gayathri Devi s2, V. V. Prasanth3 and B. Vinod4

    Affiliation(s) Name:

    1 Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore-27, India
    2 Sikkim Manipal University, Bangalore, India
    3 Goutham College of Pharmacy, Bangalore, India
    4 Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India


    Received on: 16-09-2009; Revised on: 26-12-2009; Accepted on:17-03-2010

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    Author:

    Sam T Mathew1*, Gayathri Devi s2, V. V. Prasanth3 and B. Vinod4

    Title:Suitability of Factorial Design in Determining the Processing Factors Affecting Entrapment Efficiency of Albumin Microspheres
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (May)
    Year:2010
    Page No: (1172-1177)
  • Experimental Methods Keywords

    Methodology:Factorial Design,microspheres
    Research Materials: Ketorolac tromethamine

Keywords

Ketorolac tromethamine albumin factorial design microspheres

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