Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000766
Title: Anticancer activity of Trigonella foenum-graecum on Ehrlich Ascites carcinoma in Mus musculus system
Category: Pharmacology
Section: Research Article
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    Cancer is one of the leading cause of mortality worldwide and the failure of conventional chemotherapy to effect major reduction in the mortality indicates that alternative approaches towards chemoprevention are critically needed. In this regard, plant based medicine has definitely found a role in cancer treatment. Several plants used in the Indian ethnomedicine play an important role as a source of effective anticancer agents. In the present study, anticancer activity of Trigonella foenum graecum L, a widely used medicinal and dietary herb was evaluated in Swiss albino mice Mus musculus. Mice inoculated with Ehrlich Ascites Carcinoma (EAC) cells were treated with three doses of the ethanolic extract of Trigonella foenum graecum leaves viz., 100, 200 and 400mg/kg body weight per oral for ten consecutive days. The anticancer activity of the extract was assessed based on Mean Survival Time and increase in life span in experimental animal models. In addition, hematological parameters of tumor bearing and extract treated mice were assessed. Increase in the life span was observed in the case of extract treated mice in comparison with the tumor control. Extract treatment also restored the hematological parameters in EAC inoculated mice. Thus, the present study revealed that fenugreek leaf extract showed anticancer activity in the tested animal models.

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    Author(s) Name:

    Ashwini Prabhu* and M.Krishnamoorthy

    Affiliation(s) Name:

    Department of Post graduate Studies and Research in Biosciences,Mangalore University, Mangalagangothri – 574 199, Karnataka, India

    *Corresponding author.
    Ashwini Prabhu
    Department of Post graduate Studies and Research in Biosciences,
    Mangalore University, Mangalagangothri – 574 199, Karnataka, India


    Received on: 20-02-2010; Revised on: 16-03-2010; Accepted on:15-04-2010

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    Author:

    Ashwini Prabhu* and M.Krishnamoorthy

    Title:Anticancer activity of Trigonella foenum-graecum on Ehrlich Ascites carcinoma in Mus musculus system
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (June)
    Year:2010
    Page No: (1181-1183)
  • Experimental Methods Keywords

    Methodology:Ehrlich Ascites Carcinoma, Mus musculus, Anticancer.
    Research Materials:Trigonella foenum graecum

Keywords

Trigonella foenum graecum Ehrlich Ascites Carcinoma Mus musculus Anticancer.

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