Journal: Journal of Pharmacy Research
Title: Solubility enhancement of poorly soluble drugs by solid dispersion technique – A review
Category: Pharmaceutics
Section: Review Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Currently only 8% of the new molecules have both high solubility and permeability. The drugs therapeutic efficacy depends upon the bioavailability and ultimately upon the solubility. Salt formation, particle size reduction, etc. have commonly been used to increase the dissolution rate of drugs, there are some practical limitations with these techniques the desired bioavailability enhancement may not always be achieved. Solid dispersion seems to be a viable technique for overcoming this problem. In this review, it is intended to discuss the recent advances related on the area of solid dispersion. Finally industrially feasible alternative approaches in the manufacture of solid dispersion have been highlighted.
-
Abstract Audio
About the authors and Affiliations
Author(s) Name: V. Kamalakkannan 1, A. Puratchikody2*, K. Masilamani3 , B. Senthilnathan3
Affiliation(s) Name: 1 Research scholar, Department of pharmaceutical Technology, Anna University, Tiruchirappalli 620 024, Tamil Nadu, India
2*Assistant Professor, Department of Pharmaceutical Technology and Director Academic courses, Anna University,Tiruchirappalli -620 024, Tamil Nadu, India
3 Assistant Professors, Department of Pharmaceutics, School of Pharmaceutical sciences, Vels University, Pallavaram, Chennai 600 117, Tamil Nadu, India*Corresponding author.
Puratchikody.A
Department of Pharmaceutical Technology, Anna University, Tiruchirappalli 620 024, Tamil Nadu, India Tamil Nadu, India
Received on: 14-05-2010; Revised on: 18-07-2010; Accepted on:22-08-2010-
View Article File in pdf format.
Article File
-
View Article Citation Here.
22 View More -
How to Cite my Article.
Author: V. Kamalakkannan 1, A. Puratchikody2*, K. Masilamani3 , B. Senthilnathan3
Title: Solubility enhancement of poorly soluble drugs by solid dispersion technique – A review Journal: Journal of Pharmacy Research Vol(issue): 3 (September) Year: 2010 Page No: (2314-2321) -
Experimental Methods Keywords
Methodology: Solubility enhancement Research Materials: poorly soluble drug
Keywords
Our Services
- Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats
- Solubility and Dissolution Enhancement: An overview
- In vitro antioxidant and ptp inhibitory activity of methanolic extract of Anogeissus acuminata leaf and bark.
- A review on Calotropis procera Linn and its Ethnobotany, Phytochemical, Pharmacological profile
- Antimicrobial activity and phytochemical screening of five wild plants against Escherichia coli, Bacillus subtilis and Staphylococcus aureus
- A review on quality by design approach for analytical method development
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Evaluation of Phenolic Content and Antioxidant Capacity of leaf extract from Phoenix Dactylifera L obtained by different pH of aqueous extraction
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats
- Biological synthesis of silver nanoparticles using aqueous leaf extract of Capparis decidua (FORSK.) EDGEW: A better alternative
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Study of health related quality of life in rheumatoid arthritis patients
- Prescribing Patterns of antihypertensive drugs in a South Indian tertiary care hospital
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- In vitro antioxidant, anti-inflammatory and anticholinesterase activities of Rumex vesicarius L
- Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
- Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
- In vitro anti-Candida activity of Calotropis gigantea.
- Pharmacognostic, Phytochemical & Quantitative Investigation of Saraca asoca leaves
- Anti ulcer activity of Naravelia zeylanica leaves extract
- Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study.
- Effects of Osmolytes on The Structural Stability of Bovine Trypsin: A Brief Review
- Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents
- Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent
- In vitro Antioxidant Activity from Leaves of Oroxylum indicum (L.) Vent. -A North Indian Highly Threatened and Vulnerable Medicinal Plant
- Assessment of Pharmacognostical Characters of Leaves of Tephrosia Purpurea Linn
- Genome of Acinetobacter baumannii Carries Multi Drug Resistance Genes
- Triazole analogues as novel antioxidants: In vitro bioassay and molecular modeling studies
- Anticonvulsant And Antioxidant Actions Of Some Dibenzo-a-Pyrone Derivatives In Pentylene –Induced Kindling Model In Mice