Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000773
Title: Solubility enhancement of poorly soluble drugs by solid dispersion technique – A review
Category: Pharmaceutics
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  • Abstract

    The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Currently only 8% of the new molecules have both high solubility and permeability. The drugs therapeutic efficacy depends upon the bioavailability and ultimately upon the solubility. Salt formation, particle size reduction, etc. have commonly been used to increase the dissolution rate of drugs, there are some practical limitations with these techniques the desired bioavailability enhancement may not always be achieved. Solid dispersion seems to be a viable technique for overcoming this problem. In this review, it is intended to discuss the recent advances related on the area of solid dispersion. Finally industrially feasible alternative approaches in the manufacture of solid dispersion have been highlighted.

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    Author(s) Name:

    V. Kamalakkannan 1, A. Puratchikody2*, K. Masilamani3 , B. Senthilnathan3

    Affiliation(s) Name:

    1 Research scholar, Department of pharmaceutical Technology, Anna University, Tiruchirappalli 620 024, Tamil Nadu, India
    2*Assistant Professor, Department of Pharmaceutical Technology and Director Academic courses, Anna University,Tiruchirappalli -620 024, Tamil Nadu, India
    3 Assistant Professors, Department of Pharmaceutics, School of Pharmaceutical sciences, Vels University, Pallavaram, Chennai 600 117, Tamil Nadu, India

    *Corresponding author.
    Puratchikody.A
    Department of Pharmaceutical Technology, Anna University, Tiruchirappalli 620 024, Tamil Nadu, India Tamil Nadu, India
    Received on: 14-05-2010; Revised on: 18-07-2010; Accepted on:22-08-2010

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    Author:

    V. Kamalakkannan 1, A. Puratchikody2*, K. Masilamani3 , B. Senthilnathan3

    Title:Solubility enhancement of poorly soluble drugs by solid dispersion technique – A review
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (September)
    Year:2010
    Page No: (2314-2321)
  • Experimental Methods Keywords

    Methodology:Solubility enhancement
    Research Materials:poorly soluble drug

Keywords

Solid dispersion poorly soluble drug carrier solubility bioavailability.

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