Journal: Journal of Pharmacy Research
Title: Effect of Eugenia Jambolana on Plasma Glucose, Insulin Sensitivity and HDL-C Levels: Preliminary Results of A Randomized Clinical Trial
Category: Pharmacology
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
To validate scientifically a household remedy of Eugenia jambolana seed based drug Madhuhara churna [AVA Trust Regd] in diabetes mellitus, a use based on ethnic preferences. A 6 month parallel designed open labeled randomized, controlled trial was conducted in 30 newly diagnosed type 2 diabetes mellitus. Patients were enrolled to: Group 1 (n = 15) received Madhuhara churna [AVA Trust Regd]; Group 2 (n= 5) received metformin and Group 3 (n=10) were on diet restriction and exercise therapy only. They were followed up each month for 6 months with detailed clinical examination; assessment of compliance to drug intake, diet adherence and exercise; a complete history of adverse events; different parameters to measure the efficacy were done. There was no significant difference in the baseline characteristics of patients in each of the three groups enrolled for study. The results showed a significant decrease in fasting blood glucose at 3rd (152.0 mg/dl± 22.5 to 140.7 mg/dl± 26.6, P=0.016) and 6th (152.0 mg/dl± 22.5 to 134.0 ± 21.3, P=0.043) month, homeostatic model assessment for insulin resistance at 3rd (10.3 ± 4.7 to 6.5 ± 4.1, P=0.027) month and a highly significant rise in high density lipoprotein value at 3rd (39.7 ± 9.6 to 47.3 ± 6.8, P= 0.001) month was seen in group 1 when compared to baseline values. Madhuhara churna [AVA Trust Regd] treatment in type 2 diabetic patients for 6 months has a beneficial effect in improving the glycemic profile in newly diagnosed type 2 diabetics.
-
Abstract Audio
About the authors and Affiliations
Author(s) Name: Sahana D.A1* ,Shivaprakash G1,Raghavendra Baliga1,Adhikari Prabha M.R2,Jyothi Ganesh3 ,M.R.S.M Pai1
Affiliation(s) Name: 1Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal University.
2Department of Medicine, Kasturba Medical College, Mangalore, Manipal University.
3Sri Abhinava Vidyatheertha Ayurveda Trust (Regd), Shastri’s Pharmaceuticals, M.S. Shastri sons, Kadri, Mallikatta, Mangalore-2.*Corresponding author.
Dr. Sahana D Acharya
Address: Department of Pharmacology,
Kasturba Medical College, Light House Hill road,
Mangalore 575 001, Karnataka, India.
Received on: 19-03-2010; Revised on: 13-04-2010; Accepted on:15-05-2010-
View Article File in pdf format.
Article File
-
View Article Citation Here.
15 View More -
How to Cite my Article.
Author: Sahana D.A1* ,Shivaprakash G1,Raghavendra Baliga1,Adhikari Prabha M.R2,Jyothi Ganesh3 ,M.R.S.M Pai1
Title: Effect of Eugenia Jambolana on Plasma Glucose, Insulin Sensitivity and HDL-C Levels: Preliminary Results of A Randomized Clinical Trial Journal: Journal of Pharmacy Research Vol(issue): 3 (June) Year: 2010 Page No: (1268-1270) -
Experimental Methods Keywords
Methodology: Fasting blood glucose; Homeostatic model assessment; Glycosylated hemoglobin; Diabetes mellitus Research Materials: Eugenia jambolana
Keywords
Our Services
- Estimation of orbital index for gender determination
- Morphometric analysis of gonial angle and mandibular ramus measurement as predictors of sex and age in dry human mandibles
- Abutment selection in fixed partial denture - A review
- Medicinal uses of banana (Musa paradisiaca)
- Craniometric analysis of foramen magnum with reference to occipital condyles for the determination of sex using dry human skulls
- Morphological and morphometrical analysis of Chassaignac’s tubercle in dry human cervical vertebrae
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Studies on antioxidant and anthelmintic activity of two Streptomyces species isolated from Western Ghat soils of Agumbe, Karnataka
- Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (Wall.): A comprehensive review
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Awareness and knowledge about usage of e-cigarettes and risk of cardiovascular disease among smokers
- Review On: Fast Dissolving Tablet
- Knowledge, attitude, and practices toward oral hygiene maintenance among patients visiting a dental college
- Prevalence pattern of developmental anomalies of oral cavity in South Indian population - A hospital-based study
- Awareness about oral cancer among tobacco users visiting a private dental hospital in Chennai
- Self micro-emulsifying drug delivery system (SMEDDS) : Review
- Thiophene: The molecule of diverse medicinal importance
- QbD Approach for Analytical Method Development and Validation of Melatonin by spectroscopic Method
- Evaluating the effects of video games on blood pressure and heart rate
- A study of the factors affecting time to onset of lactogenesis-II after parturition
- Knowledge and awareness among undergraduate dental students regarding oral health of diabetes mellitus patients
- Awareness on soil pollution among school students
- Anticancer activity of L-theanine in MG-63 cell line
- Combinatory effect of embelin with antibiotics against Staphylococcus aureus
- Pharmaceutical and medicinal applications of Olibanum gum and its constituents : A review
- In vitro anti-Candida activity of Calotropis gigantea.
- Awareness of anemia among dental undergraduate students: A questionnaire-based study
- Impurity profile- A review
- Antihypertensive activity of ethanolic extract of Acacia nilotica
- Assessment of clinical skills of students in fixed partial denture