Journal: Journal of Pharmacy Research
Title: Effect of Eugenia Jambolana on Plasma Glucose, Insulin Sensitivity and HDL-C Levels: Preliminary Results of A Randomized Clinical Trial
Category: Pharmacology
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Abstract
To validate scientifically a household remedy of Eugenia jambolana seed based drug Madhuhara churna [AVA Trust Regd] in diabetes mellitus, a use based on ethnic preferences. A 6 month parallel designed open labeled randomized, controlled trial was conducted in 30 newly diagnosed type 2 diabetes mellitus. Patients were enrolled to: Group 1 (n = 15) received Madhuhara churna [AVA Trust Regd]; Group 2 (n= 5) received metformin and Group 3 (n=10) were on diet restriction and exercise therapy only. They were followed up each month for 6 months with detailed clinical examination; assessment of compliance to drug intake, diet adherence and exercise; a complete history of adverse events; different parameters to measure the efficacy were done. There was no significant difference in the baseline characteristics of patients in each of the three groups enrolled for study. The results showed a significant decrease in fasting blood glucose at 3rd (152.0 mg/dl± 22.5 to 140.7 mg/dl± 26.6, P=0.016) and 6th (152.0 mg/dl± 22.5 to 134.0 ± 21.3, P=0.043) month, homeostatic model assessment for insulin resistance at 3rd (10.3 ± 4.7 to 6.5 ± 4.1, P=0.027) month and a highly significant rise in high density lipoprotein value at 3rd (39.7 ± 9.6 to 47.3 ± 6.8, P= 0.001) month was seen in group 1 when compared to baseline values. Madhuhara churna [AVA Trust Regd] treatment in type 2 diabetic patients for 6 months has a beneficial effect in improving the glycemic profile in newly diagnosed type 2 diabetics.
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About the authors and Affiliations
Author(s) Name: Sahana D.A1* ,Shivaprakash G1,Raghavendra Baliga1,Adhikari Prabha M.R2,Jyothi Ganesh3 ,M.R.S.M Pai1
Affiliation(s) Name: 1Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal University.
2Department of Medicine, Kasturba Medical College, Mangalore, Manipal University.
3Sri Abhinava Vidyatheertha Ayurveda Trust (Regd), Shastri’s Pharmaceuticals, M.S. Shastri sons, Kadri, Mallikatta, Mangalore-2.*Corresponding author.
Dr. Sahana D Acharya
Address: Department of Pharmacology,
Kasturba Medical College, Light House Hill road,
Mangalore 575 001, Karnataka, India.
Received on: 19-03-2010; Revised on: 13-04-2010; Accepted on:15-05-2010-
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Author: Sahana D.A1* ,Shivaprakash G1,Raghavendra Baliga1,Adhikari Prabha M.R2,Jyothi Ganesh3 ,M.R.S.M Pai1
Title: Effect of Eugenia Jambolana on Plasma Glucose, Insulin Sensitivity and HDL-C Levels: Preliminary Results of A Randomized Clinical Trial Journal: Journal of Pharmacy Research Vol(issue): 3 (June) Year: 2010 Page No: (1268-1270) -
Experimental Methods Keywords
Methodology: Fasting blood glucose; Homeostatic model assessment; Glycosylated hemoglobin; Diabetes mellitus Research Materials: Eugenia jambolana
Keywords
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