Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000805
Title: Pharmacological evaluation of ethanolic extracts of the plant Alternanthera sessilis against temperature regulation
Category: Pharmacology
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    Purpose: The antipyretic activity of the 90 % ethanol extract of the aerial parts of Alternanthera sessilis. (Amaranthaceae) was investigated in other to verify its claimed ethno medicinal use in the treatment of fever.Method: The antipyretic activity of Alternanthera sessilis extract (ASE) was investigated for its, potential on normal body temperature and yeast-induced pyrexia in albino rats. Results: The ASE at doses of 200, and 400 mg/kgBW p.o., showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect also extended upto 4 h after the drug administration. The anti-pyretic effect of ASE was comparable to that of paracetamol (150 mg/kg p.o.,), a standard anti-pyretic agent. Conclusion: Based on the results of the present study it can be concluded that the extract of A. sessilis has potential antipyretic activity. The activity is in dose dependent manner.Consequently our present study gives a scientific ground to the traditional uses of the plant A.sessilis

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    Author(s) Name:

    Praveen Nayak1, * Shweta Nayak1, DM Kar2, Prabhat Das1

    Affiliation(s) Name:

    1GRY Institute of Pharmacy, Vidya Vihar, Borawan, Khargone, MP- 451228.
    2SPS, SOA University Bhubaneswar, Orissa

    *Corresponding author.
    Praveen Singh Nayak
    GRY Institute of Pharmacy, Vidya Vihar, Borawan, Khargone, MP- 451228


    Received on: 11-03-2010; Revised on: 19-04-2010; Accepted on:25-05-2010

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    Author:

    Praveen Nayak1, * Shweta Nayak1, DM Kar2, Prabhat Das1

    Title:Pharmacological evaluation of ethanolic extracts of the plant Alternanthera sessilis against temperature regulation
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (June)
    Year:2010
    Page No: (1381-1383)
  • Experimental Methods Keywords

    Methodology:Pharmacological evaluation
    Research Materials:Alternanthera sessilis, yeast-induced pyrexia, antipyretic activity

Keywords

Alternanthera sessilis yeast-induced pyrexia antipyretic activity

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