Journal: Journal of Pharmacy Research

Article Id: JPRS-QA-000081
Title: Development and validation of an UV spectrophotometric method for simultaneous determination of chlorthalidone and losartan potassium
Category: Quality Assurance
Section: Research Article
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  • Abstract

    A new, simple, rapid and novel spectrophotometric method has been developed for simultaneous estimation of Chlorthalidone (CLR) and Losartan Potassium (LOS). The combination is estimated by AUC method . It involved measurement of area under curve in the wavelength range 280-290.5 and 235-245 for Chlorthalidone and Losartan Potassium respectively. Beer’s law obeyed in concentration range of 2-10 μg/ ml and 4-20 μg/ ml for Chlorthalidone and Losartan Potassium respectively. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific. It involves no heating and no organic solvent extraction. These method was validated for precision, reproducibility, linearity and accuracy as per ICH guidelines.

    Cite this article as: Varsha M. Bhanushali, Madhuri A. Hinge, Snehal N. Patel,Development and validation of an UV spectrophotometric method for simultaneous determination of chlorthalidone and losartan potassium,Journal of Pharmacy Research 2015,9(1),54-59.

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    Author(s) Name:

    Varsha M. Bhanushali1*, Madhuri A. Hinge1, Snehal N. Patel1

    Affiliation(s) Name:

    1Department of Quality Assurance , Rofel Shri G.M. Bilakhia College of Pharmacy, Vapi , Gujarat , India.

    *Corresponding author.
    Varsha M. Bhanushali
    Rofel Shri G.M. Bilakhia College of Pharmacy,
    Vapi,Gujarat,India.
    Email.: varsha315pharma@gmail.com


    Received on:27-10-2014; Revised on: 19-12-2014; Accepted on:21-01-2015

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    Author:

    Varsha M. Bhanushali1*, Madhuri A. Hinge1, Snehal N. Patel1

    Title:Development and validation of an UV spectrophotometric method for simultaneous determination of chlorthalidone and losartan potassium
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (January )
    Year:2015
    Page No: (54-59)
  • Experimental Methods Keywords

    Methodology:Spectrophotometric method
    Research Materials: Chlorthalidone, Losartan potassium,

Keywords

Chlorthalidone Losartan potassium Spectrophotometric method Area under curve method.

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