Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000821
Title: Comparative Study of Ionotropic Gelation Technique To Entrap Diltiazem HCl In Mucoadhesive Microparticulate System.
Category: Pharmaceutics
Section: Research Article
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    The aim of present investigation was to compare the ionotropic gelation techniques for entrapping water soluble drug Diltiazem HCl in mucoadhesive microparticulate system. Mucoadhesive polymers HPMC K15 and Carbapol 934 were used in combination with sodium alginate which provides gastric retention for prolonged time. Diltiazem HCl microcapsules were formulated by orifice-ionic and emulsification-ionic gelation technique. The formulated microcapsules of Diltiazem HCl were evaluated for the following parameters viz. Particle size, entrapment efficiency, in-vitro drug release and percent mucoadhesive strength. FT-IR and SEM were used to characterize microcapsules. The results of both techniques were compared. It was evident from study that, the entrapment efficiency of Diltiazem HCl was improved (46% - 61%) in emulsification-ionic gelation technique, as compared to orifice-ionic gelation technique (<15%). Thus it was concluded that emulsification-ionic gelation technique is superior to orifice-ionic gelation technique to entrap water soluble drug Diltiazem HCl. The drug release from the microcapsules were found to be slow and spread over extended period of time, drug release depends on the percent of coat material, wall thickness and size of microcapsule. Microcapsule with a coat comprised sodium alginate, HPMC and carbapol exhibited good mucoadhesive properties as observed in in-vitro wash-off test.

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    Author(s) Name:

    Tirupati M. Rasala.*, Govind K. lohiya, Vinita V. Kale., Jasmine G. Avari

    Affiliation(s) Name:

    Gurunanak College of pharmacy, Nagpur

    *Corresponding author.
    Tirupati M. Rasala.
    Gurunanak College of pharmacy, Nagpur

    Received on: 12-04-2010; Revised on: 126-05-2010; Accepted on:19-06-2010

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    Author:

    Tirupati M. Rasala.*, Govind K. lohiya, Vinita V. Kale., Jasmine G. Avari

    Title:Comparative Study of Ionotropic Gelation Technique To Entrap Diltiazem HCl In Mucoadhesive Microparticulate System.
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (July)
    Year:2010
    Page No: (1531-1543)
  • Experimental Methods Keywords

    Methodology:Comparative Study of Ionotropic Gelation Technique,Ionotropic-gelation method, DDS, DEE,
    Research Materials:Diltiazem HCl

Keywords

Mucoadhesion Microcapsule Ionotropic-gelation method DDS DEE

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