Journal: Journal of Pharmacy Research

Article Id: JPRS-PRGS-0000832
Title: Comparative study of mineralo-herbal drugs (Kamadugha and Sutshekhar Rasa Sada) on gastric ulcer in experimental rats
Category: Pharmaceutical and Related General Science
Section: Research Article
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    There are number of mineralo-herbal formulations which are prescribed by the local prescribers but their scientific evaluation is not made yet. After realizing the potential use of these mineralo-herbal formulations in ulcer treatment, the present study was undertaken to study the effect of these formulations on different gastric ulcer models in rats. In this, acute toxicities study and antiulcer activity was evaluated using different ulcer models- cold restraint induced ulcers (CRU), pylorus-ligation (PL), ethanol-induced ulcers (EtOH), and indomethacin (INDO) induced ulcers model. In CRU model the Kamadugha (KD) and Sutshekhar Rasa Sada (SRS) significantly inhibited the formation of gastric lesions induced by cold restraint-stress by 74.37% and 74.83% respectively. Animals in the PL group showed a significant increase in the ulcer index and acid secretory parameters like gastric volume, pH, free and total acidity when compared with those of vehicle treated group. KD and SRS at a dose of 40 mg/kg body weight each showed protection index of 47.59% and 50.69%, respectively in EtOH model. In INDO model, the inhibition of ulcers were 55.91%, 57.52% for groups treated with KD and SRS each of 40 mg/kg and 66.13% with positive control (lansoprazole), respectively. From the results, KD shows better results in pylorus ligation model where as the SRS performs better in the rest of the other models.

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    Author(s) Name:

    Phool Chandra*a, Neetu Sachana, A. K. Gangwarb and P. K. Sharmac

    Affiliation(s) Name:

    aCollege of Pharmacy, Institute of Foreign Trade & Management (IFTM), Lodhipur Rajput, Delhi Road, Moradabad-244 001, UP, (India).
    bRakshpal Bahadur College of Pharmacy, Near-ITBP, Bakara More, Bareilly-243 001, UP, (India).
    cDepartment of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut-250 005, UP, (India).


    Received on: 15-04-2010; Revised on: 12-05-2010; Accepted on:13-06-2010

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    Author:

    Phool Chandra*a, Neetu Sachana, A. K. Gangwarb and P. K. Sharmac

    Title:Comparative study of mineralo-herbal drugs (Kamadugha and Sutshekhar Rasa Sada) on gastric ulcer in experimental rats
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (July)
    Year:2010
    Page No: (1659-1662)
  • Experimental Methods Keywords

    Methodology: Gastroprotective, Kamadugha, Sutshekhar Rasa Sada,
    Research Materials:Mineralo-herbal

Keywords

Mineralo-herbal Gastroprotective Kamadugha Sutshekhar Rasa Sada

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