Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000846
Title: Formulation and Evaluation of Nifedipine Transdermal Patches
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    Transdermal patches of nifedipine with different composition of PVP and PVA polymers were prepared by moulding technique. The physicochemical parameters such as appearance, thickness, weight, folding endurance, moisture absorption, percentage elongation and tensile strength were evaluated. Patches containing 3:2 ratio of PVA: PVP were found to be yellow in color, homogenous and flexible compared to others. The thickness and weight of all patches were in the range of 0.12 to 0.28 mm and 17.26 to 38.60 mg/cm2 respectively. Moisture absorption was increased as the concentration of PVP was increased. All the patches exhibited adequate folding endurance and good drug content uniformity. In vitro release profiles of the drug from different patches were studied using abdominal skin of albino rats and modified Keshary Chein diffusion cell. In vitro drug release studies were extended up to 24 hrs and it was found that, as the concentration of PVP increased the drug release was also increased. Polymers and their combination influenced the film properties as well as the release characteristics. Effect of penetration enhancers on the in- vitro permeation of nifedipine across rat abdominal skin was carried out for patches with 3 different types of penetration enhancers showed all the patches with permeation enhancer increased the permeation of the drug from the membrane.

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    Author(s) Name:

    Mohammed Gulzar Ahmed*,Kiran Kumar GB and Satish Kumar BP

    Affiliation(s) Name:

    Dept of Pharmaceutics, SAC College of Pharmacy, BG Nagar, India.

    *Corresponding author.
    Mohammed Gulzar Ahmed,
    Professor and Head, Department of Pharmaceutics
    S.A.C. College of Pharmacy,
    B.G. Nagar, Karnataka, India.


    Received on: 15-04-2010; Revised on: 15-05-2010; Accepted on:16-07-2010

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    Author:

    Mohammed Gulzar Ahmed*,Kiran Kumar GB and Satish Kumar BP

    Title:Formulation and Evaluation of Nifedipine Transdermal Patches
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (August)
    Year:2010
    Page No: (1785-1787)
  • Experimental Methods Keywords

    Methodology:Formulation and Evaluation
    Research Materials:Nifedipine

Keywords

Nifedipine Transdermal Patches Penetration Enhancer Plasticizer.

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