Journal: Drug Invention Today

Article Id: JPRS-PS-0000854
Title: Antioxidant potential of a polyherbal formulation (Diabet) on alloxan induced oxidative stress in rats
Category: Pharmacological Screening
Section: Research Article
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  • Abstract

    Diabet, a polyherbal formulation intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, Diabet was administered orally for 30 days at a dose of 500 mg/kg body weight to alloxan induced diabetic male Wistar rats. All the animals were sacrificed on the 31st day and the levels of LPO, SOD, CAT, GPx and GSH in kidney and liver of control and experimental rats were studied. The formulation exhibited significant antioxidant activity showing increased levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and decreased level of lipid peroxidation. These results showed that treatment with Diabet lowers Alloxan induced LPO and alters SOD, CAT, GPx and GSH enzymes to reduce oxidative stress.

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    Author(s) Name:

    Umamaheswari.S*1, Prathiba.D**, Srikanth.J*, Umamaheswara Reddy*

    Affiliation(s) Name:

    *Department of Pharmacology, Sri Ramachandra College of pharmacy, Sri Ramachandra University, Porur, Chennai-600 116.
    **Department of Pathology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai-600 116.

    *Corresponding author.
    Dr.S.Umamaheswari,
    Department of Pharmacology,
    Sri Ramachandra College of pharmacy,
    Sri Ramachandra University,
    Porur, Chennai-600 116,
    Tamil Nadu, India.


    Received on: 09-07-2009; Revised on: 21-08- 2009; Accepted on:09-10-2009

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    Author:

    Umamaheswari.S*1, Prathiba.D**, Srikanth.J*, Umamaheswara Reddy*

    Title:Antioxidant potential of a polyherbal formulation (Diabet) on alloxan induced oxidative stress in rats
    Journal:Drug Invention Today
    Vol(issue):1 (January 2009)
    Year:2009
    Page No: (46-49)
  • Experimental Methods Keywords

    Methodology:Marker enzymes in liver and kidney; Antioxidant activity
    Research Materials:Polyherbal formulation (Diabet)

Keywords

Diabet; Alloxan; Marker enzymes in liver and kidney; Antioxidant activity

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