Journal: Drug Invention Today

Article Id: JPRS-PS-0000855
Title: Evaluation of Nephroprotective and antioxidant potential of Tragia involucrata
Category: Pharmacological Screening
Section: Research Article
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    Tragia involucrata (TI) Linn is a shrub belongs to family Ephorbiaceae widely distributed in the Indian subcontinent. TI is used for treatment of various diseases including eczema, inflammation, superficial skin infections. Juice from its leaves is commonly used for illnesses including liver and renal conditions in the Asian subcontinent. The aim of this study was to investigate the nephroprotective and antioxidant activities of ethanol extract of TI at two dose levels of 250 and 500 mg/kg B/W on acetaminophen (APAP) induced toxicity in male albino rats. APAP significantly increased levels of serum urea, hemoglobin (Hb), total leukocyte count, packed cell volume,creatinine, , DLC, and mean corpuscular volume, raised body weight, and reduced levels of neutrophils, mean corpuscular Hb content, mean corpuscular hematocrit, granulocytes, uric acid, and platelet Concentration. TI inhibited the hematological effects of APAP. TI significantly increased activities of renal superoxide dismutase, catalase, glutathione, and glutathione peroxidase and decreased malondialdehyde content of APAP-treated rats. Apart from these, histopathological changes also showed the protective nature of the TI extract against APAP induced necrotic damage of renal tissues. In conclusion it was observed that the ethanol extract of AC conferred nephroprotective and antioxidant activities by histopathological and biochemical observations against APAP induced renal damage in rats.

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    Author(s) Name:

    *S. Palani1&3, S. Nirmal Kumar1, R.Gokulan1, D.Rajalingam2 , B. Senthil Kumar3

    Affiliation(s) Name:

    1Dept of Biotechnology, Anna Bioresearch Foundation, Arunai Engineering College, Tiruvannamalai, Tamil Nadu, India.
    2 Dept of Pharmaceutical chemistry, K.P.College of Pharmacy, Tiruvannamalai, Tamil Nadu, India.
    3 PG Research, Dept of Zoology, C Abdul Hakeem College, Melvisharam, Tamil Nadu, India.

    *Corresponding author.
    S. Palani,
    Department of Biotechnology,
    Anna Bioresearch foundation, Arunai Engineering College,
    Tiruvannamalai – 606603, Tamilnadu, India.


    Received on: 09-07-2009; Revised on: 21-08- 2009; Accepted on:15-10-2009

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    Author:

    *S. Palani1&3, S. Nirmal Kumar1, R.Gokulan1, D.Rajalingam2 , B. Senthil Kumar3

    Title:Evaluation of Nephroprotective and antioxidant potential of Tragia involucrata
    Journal:Drug Invention Today
    Vol(issue):1 (January 2009)
    Year:2009
    Page No: (55-60)
  • Experimental Methods Keywords

    Methodology:Nephroprotective and antioxidant potential
    Research Materials:Tragia involucrata

Keywords

Tragia involucrata nephroprotective antioxidant Acetaminophen

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