Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-000086
Title: Effect of B.diffusa root extracts on ex vivo and Cu++ -mediated in vitro susceptibility of LDL, sd-LDL and lb-LDL to oxidation in absence or presence of glucose in diabetic-hyperlipidemic rats
Category: Pharmacology
Section: Research Article
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    Background: The prevalence of diabetes mellitus (DM) for all age group worldwide is quite high. In India the total number of subjects with DM is projected to increase from 31.7 million in 2000 to 79.4 million in 2030. Boerhaavia diffusa is a member of Nyctaginaceae family. It is a perennial creeping weed, a number of branches spread out from the node of main stem and cover most of the surrounding area.In India it is commonly known as ‘punarnava’ where it has a long history of use by indigenous and tribal people and in Ayurvedic herbal medicine systems. Methods: In this study we tried to check the effect of B.diffusa on ex vivo and Cu++-mediated invitro susceptibility of LDL, sd-LDL and lb-LDL to oxidation in absence or presence of glucose in diabetic-hyperlipidemic rats. Results: Our results demonstrate that even in normal animals, relative to lb-LDL, the invivo oxidizability of sd-LDL, measured as base line diene conjugation (BDC) was higher by 2.90-fold, which was further increased to 3.3-fold due to diabetes. Similarly, in comparison to a lag phase value of 53 min for lb-LDL in normal rats, sd-LDL lag phase was reduced to only 15.0 min, which was further shortened to 9.6 min in diabetic rats, indicating a substantially enhanced Cu++-catalyzed sd- LDL oxidizability. Conclusion: Dietary B. diffusa aqueous and methanolic root extracts due to their potent antioxidative properties can provide additional benefits in the inhibition of oxidative stress, particularly in the resistance of highly atherogenic sd-LDL to oxidation and hence in the prevention and treatment of both type 1 and type 2 diabetes.

    DOI:https://dx.doi.org/10.6084/m9.figshare.3168118

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    Author(s) Name:

    Deepti Malhotra1, Fouzia Ishaq2 and Amir Khan3*

    Affiliation(s) Name:

    1Department of Biotechnology, Shri Guru Ram Rai (P.G.) College, Dehradun (Uttarakhand) India.
    2Limnological Research Lab. Deptt. of Zoology and Environmental Science, Gurukula Kangri University, Haridwar, UK, India.
    *3Glocal School of Life Science,The Glocal University (GU), Ali Akbarpur, Mirzapur PolSaharanpur, 247001, (UP) India

     

    *Corresponding author.
    Dr.Amir Khan
    *3 Glocal School of Life Science,
    The Glocal University (GU),
    Ali Akbarpur, Mirzapur Pol
    Saharanpur, 247001, (UP) India

    E-mail: amiramu@gmail.com

    Received on:21-11-2013; Revised on: 08-12-2013; Accepted on:14-12-2013

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    Author:

    Deepti Malhotra1, Fouzia Ishaq2 and Amir Khan3*

    Title:Effect of B.diffusa root extracts on ex vivo and Cu++ -mediated in vitro susceptibility of LDL, sd-LDL and lb-LDL to oxidation in absence or presence of glucose in diabetic-hyperlipidemic rats
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (January )
    Year:2014
    Page No: (7-11)
  • Experimental Methods Keywords

    Methodology:Streptozotocin (STZ), Lipid content ,LDL, sd-LDL and lb-LDL,
    Research Materials:Boerhaavia diffusa

Keywords

antidiabetic hyperlipidemic Boerhaavia diffusa.

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