Journal: Drug Invention Today
Title: Effect of manufacturing conditions on physico-chemical characteristics and drug release profiles of aceclofenac sodium microbeads
Category: Drug Release Profiles
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
The present study reports the optimization of sustained release microbeads of aceclofenac sodium were prepared by ionotropic gelation technique, using different variables such as drug-polymer ratios, concentration of cross-linking agent, cross-linking time. The effects of these processing variables were evaluated on physicochemical properties and drug release potential of microbeads. .The shape and surface characteristics were determined by scanning electron microscopy (SEM). While increasing in the concentration of sodium alginate dispersion increased sphericity, size distribution, flow properties, mean particle size, swelling ratio and drug entrapment efficiency. While increasing cross-linking time was significantly decreases the mean particle size. The mean particle sizes of microbeads were found to be in the range 596.45±1.04 to 880.10±0.13μm. The drug entrapment efficiency was obtained in the range of 63.24-98.90%w/v. No significant drug-polymer interactions were observed in FT-IR studies. In-vitro drug release profile of aceclofenac sodium from microbeads was examined in simulated gastric fluid pH1.2 for initial 2h, mixed phosphate buffer pH 6.8 up to 6h and simulated intestinal pH 7.2 at end of 24h. The release of drug from the microbeads was pH dependent, showed negligible drug release in pH1.2. Under neutral conditions the beads will swell and the drug release depend on swelling and erosion process resulting optimum level of drug released in a sustained manner and exhibited zero-order kinetics. Aceclofenac sodium microbeads prepared by ionotropic gelation method using natural polysaccharide like sodium alginate showed a satisfactory sustained release profile and minimizing dose related side effects. The entire process is feasible in an industrial scale and
demands pilot study. -
Abstract Audio
About the authors and Affiliations
Author(s) Name: * K.M.Manjanna, 1T.M. Pramod Kumar.2B. Shivakumar
Affiliation(s) Name: *Department of Pharmaceutics, T.V.M.College of Pharmacy, Bellary Karnataka, India
1Department of Pharmaceutics, J.S.S. College of Pharmacy, Mysore, Karnataka, India.
2Department of Pharmaceutical Chemistry, S.C.S.College of Pharmacy, Harapanahalli, Karnataka, India.*Corresponding author.
K.M.Manjanna
Department of Pharmaceutics,
T.V.M.College of Pharmacy,
Bellary Karnataka, India
Received on: 25-07-2009; Revised on: 21-08- 2009; Accepted on:12-10-2009-
View Article File in pdf format.
Article File
-
View Article Citation Here.
3 View More -
How to Cite my Article.
Author: * K.M.Manjanna, 1T.M. Pramod Kumar.2B. Shivakumar
Title: Effect of manufacturing conditions on physico-chemical characteristics and drug release profiles of aceclofenac sodium microbeads Journal: Drug Invention Today Vol(issue): 1 (December) Year: 2009 Page No: (98-107) -
Experimental Methods Keywords
Methodology: Sustained Drug Release,solubility study: Research Materials: aceclofenac sodium
Keywords
Our Services
- Correlation of facial and nasal index in gender determination
- Morphometric analysis of gonial angle and mandibular ramus measurement as predictors of sex and age in dry human mandibles
- Medicinal uses of banana (Musa paradisiaca)
- Abutment selection in fixed partial denture - A review
- Craniometric analysis of foramen magnum with reference to occipital condyles for the determination of sex using dry human skulls
- Morphological and morphometrical analysis of Chassaignac’s tubercle in dry human cervical vertebrae
- Studies on antioxidant and anthelmintic activity of two Streptomyces species isolated from Western Ghat soils of Agumbe, Karnataka
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (Wall.): A comprehensive review
- Review On: Fast Dissolving Tablet
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Knowledge, attitude, and practices toward oral hygiene maintenance among patients visiting a dental college
- Prevalence pattern of developmental anomalies of oral cavity in South Indian population - A hospital-based study
- Self micro-emulsifying drug delivery system (SMEDDS) : Review
- Awareness about oral cancer among tobacco users visiting a private dental hospital in Chennai
- Thiophene: The molecule of diverse medicinal importance
- QbD Approach for Analytical Method Development and Validation of Melatonin by spectroscopic Method
- Knowledge and awareness among undergraduate dental students regarding oral health of diabetes mellitus patients
- Evaluating the effects of video games on blood pressure and heart rate
- Awareness and knowledge about usage of e-cigarettes and risk of cardiovascular disease among smokers
- Anticancer activity of L-theanine in MG-63 cell line
- Combinatory effect of embelin with antibiotics against Staphylococcus aureus
- Pharmaceutical and medicinal applications of Olibanum gum and its constituents : A review
- In vitro anti-Candida activity of Calotropis gigantea.
- A study of the factors affecting time to onset of lactogenesis-II after parturition
- Awareness of anemia among dental undergraduate students: A questionnaire-based study
- Impurity profile- A review
- Antihypertensive activity of ethanolic extract of Acacia nilotica
- Assessment of clinical skills of students in fixed partial denture
- Awareness on soil pollution among school students