Journal: Drug Invention Today
Title: Effect of manufacturing conditions on physico-chemical characteristics and drug release profiles of aceclofenac sodium microbeads
Category: Drug Release Profiles
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
The present study reports the optimization of sustained release microbeads of aceclofenac sodium were prepared by ionotropic gelation technique, using different variables such as drug-polymer ratios, concentration of cross-linking agent, cross-linking time. The effects of these processing variables were evaluated on physicochemical properties and drug release potential of microbeads. .The shape and surface characteristics were determined by scanning electron microscopy (SEM). While increasing in the concentration of sodium alginate dispersion increased sphericity, size distribution, flow properties, mean particle size, swelling ratio and drug entrapment efficiency. While increasing cross-linking time was significantly decreases the mean particle size. The mean particle sizes of microbeads were found to be in the range 596.45±1.04 to 880.10±0.13μm. The drug entrapment efficiency was obtained in the range of 63.24-98.90%w/v. No significant drug-polymer interactions were observed in FT-IR studies. In-vitro drug release profile of aceclofenac sodium from microbeads was examined in simulated gastric fluid pH1.2 for initial 2h, mixed phosphate buffer pH 6.8 up to 6h and simulated intestinal pH 7.2 at end of 24h. The release of drug from the microbeads was pH dependent, showed negligible drug release in pH1.2. Under neutral conditions the beads will swell and the drug release depend on swelling and erosion process resulting optimum level of drug released in a sustained manner and exhibited zero-order kinetics. Aceclofenac sodium microbeads prepared by ionotropic gelation method using natural polysaccharide like sodium alginate showed a satisfactory sustained release profile and minimizing dose related side effects. The entire process is feasible in an industrial scale and
demands pilot study. -
Abstract Audio
About the authors and Affiliations
Author(s) Name: * K.M.Manjanna, 1T.M. Pramod Kumar.2B. Shivakumar
Affiliation(s) Name: *Department of Pharmaceutics, T.V.M.College of Pharmacy, Bellary Karnataka, India
1Department of Pharmaceutics, J.S.S. College of Pharmacy, Mysore, Karnataka, India.
2Department of Pharmaceutical Chemistry, S.C.S.College of Pharmacy, Harapanahalli, Karnataka, India.*Corresponding author.
K.M.Manjanna
Department of Pharmaceutics,
T.V.M.College of Pharmacy,
Bellary Karnataka, India
Received on: 25-07-2009; Revised on: 21-08- 2009; Accepted on:12-10-2009-
View Article File in pdf format.
Article File
-
View Article Citation Here.
3 View More -
How to Cite my Article.
Author: * K.M.Manjanna, 1T.M. Pramod Kumar.2B. Shivakumar
Title: Effect of manufacturing conditions on physico-chemical characteristics and drug release profiles of aceclofenac sodium microbeads Journal: Drug Invention Today Vol(issue): 1 (December) Year: 2009 Page No: (98-107) -
Experimental Methods Keywords
Methodology: Sustained Drug Release,solubility study: Research Materials: aceclofenac sodium
Keywords
Our Services
- Solubility and Dissolution Enhancement: An overview
- Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats
- Ethosomes: A novel tool for drug delivery through the skin
- A review on quality by design approach for analytical method development
- Evaluation of Phenolic Content and Antioxidant Capacity of leaf extract from Phoenix Dactylifera L obtained by different pH of aqueous extraction
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Biological synthesis of silver nanoparticles using aqueous leaf extract of Capparis decidua (FORSK.) EDGEW: A better alternative
- Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats
- Study of health related quality of life in rheumatoid arthritis patients
- In vitro antioxidant, anti-inflammatory and anticholinesterase activities of Rumex vesicarius L
- Prescribing Patterns of antihypertensive drugs in a South Indian tertiary care hospital
- Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
- In vitro anti-Candida activity of Calotropis gigantea.
- Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study.
- Anti ulcer activity of Naravelia zeylanica leaves extract
- Pharmacognostic, Phytochemical & Quantitative Investigation of Saraca asoca leaves
- Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents
- Effects of Osmolytes on The Structural Stability of Bovine Trypsin: A Brief Review
- Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent
- Genome of Acinetobacter baumannii Carries Multi Drug Resistance Genes
- Triazole analogues as novel antioxidants: In vitro bioassay and molecular modeling studies
- In vitro Antioxidant Activity from Leaves of Oroxylum indicum (L.) Vent. -A North Indian Highly Threatened and Vulnerable Medicinal Plant
- In vitro antioxidant and ptp inhibitory activity of methanolic extract of Anogeissus acuminata leaf and bark.
- Anticonvulsant And Antioxidant Actions Of Some Dibenzo-a-Pyrone Derivatives In Pentylene –Induced Kindling Model In Mice
- Assessment of Pharmacognostical Characters of Leaves of Tephrosia Purpurea Linn
- FORMULATION AND IN VITRO EVALUATION OF NIOSOME ENCAPSULATED ACYCLOVIR
- Phytochemical Screening and Evaluation of Polyphenols, Flavonoids and Antioxidant Activity of Prunus cerasoides D. Don Leaves