Journal: Drug Invention Today

Article Id: JPRS-PS-0000865
Title: Antidepressant activity of the ethanolic extract of Albizzia lebbeck (Linn) bark in animal models of depression
Category: Pharmacological Screening
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    Objectives: The present study was designed to investigate the antidepressant effects of Albizzia lebbeck bark in various animal depression models.Materials and Methods: The alcoholic extract (70% v/v ethanol) of Albizzia lebbeck bark (200 & 400 mg/kg. p.o) was administered once daily for seven successive days to separate groups of young male swiss albino mice. The immobility periods of control and treated mice were recorded in two behavioral despair models forced swim test (FST), tail suspension test (TST) and the effect of extract on locomotor function of mice was studied using actophotometer. The antidepressant-like effect of tested drug was compared to that of imipramine (15 mg/ kg. p.o) and fluoxetine (20mg/kg.p.o). Results: The bark extract at doses of 200 and 400 mg/kg significantly decreased the duration of immobility time in a dose dependent manner in both FST and TST. The extract did not show significant effect on locomotor activity of mice. The efficacy of tested extract was found to be comparable to that of imipramine and fluoxetine. Conclusion: Our results suggested that the ethanolic extract of Albizzia lebbeck bark exerts antidepressant-like effect.

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    Author(s) Name:

    Malarkodi Velraj *1, A. Vijayalakshmi1, S. Jayakumari1, S. Ramamoorthy1,V. Ravichandiran1 & J.Srikanth2.

    Affiliation(s) Name:

    1*Department of Pharmacognosy, Vels school of pharmaceutical sciences, Vels University, Pallavaram, Chennai – 600 043, Tamil Nadu, India.
    2Department of pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600 116, Tamil Nadu, India.

    *Corresponding author.
    *Mrs. Malarkodi Velraj
    Department of Pharmacognosy,
    Vels school of pharmaceutical sciences,
    Vels University, Pallavaram,
    Chennai – 117,
    Tamil Nadu, India.


    Received on: 20-07-2009; Revised on: 21-08- 2009; Accepted on:15-10-2009

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    Author:

    Malarkodi Velraj *1, A. Vijayalakshmi1, S. Jayakumari1, S. Ramamoorthy1,V. Ravichandiran1 & J.Srikanth2.

    Title:Antidepressant activity of the ethanolic extract of Albizzia lebbeck (Linn) bark in animal models of depression
    Journal:Drug Invention Today
    Vol(issue):1(2)
    Year:2009
    Page No: (112-115)
  • Experimental Methods Keywords

    Methodology:Antidepressant activity,Depression, Forced swim test, Tail suspension test.
    Research Materials:Albizzia lebbeck (Linn) bark

Keywords

Albizzia lebbeck Depression Forced swim test Tail suspension test.

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