Journal: Drug Invention Today
Title: Antidepressant activity of the ethanolic extract of Albizzia lebbeck (Linn) bark in animal models of depression
Category: Pharmacological Screening
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
Objectives: The present study was designed to investigate the antidepressant effects of Albizzia lebbeck bark in various animal depression models.Materials and Methods: The alcoholic extract (70% v/v ethanol) of Albizzia lebbeck bark (200 & 400 mg/kg. p.o) was administered once daily for seven successive days to separate groups of young male swiss albino mice. The immobility periods of control and treated mice were recorded in two behavioral despair models forced swim test (FST), tail suspension test (TST) and the effect of extract on locomotor function of mice was studied using actophotometer. The antidepressant-like effect of tested drug was compared to that of imipramine (15 mg/ kg. p.o) and fluoxetine (20mg/kg.p.o). Results: The bark extract at doses of 200 and 400 mg/kg significantly decreased the duration of immobility time in a dose dependent manner in both FST and TST. The extract did not show significant effect on locomotor activity of mice. The efficacy of tested extract was found to be comparable to that of imipramine and fluoxetine. Conclusion: Our results suggested that the ethanolic extract of Albizzia lebbeck bark exerts antidepressant-like effect.
-
Abstract Audio
About the authors and Affiliations
Author(s) Name: Malarkodi Velraj *1, A. Vijayalakshmi1, S. Jayakumari1, S. Ramamoorthy1,V. Ravichandiran1 & J.Srikanth2.
Affiliation(s) Name: 1*Department of Pharmacognosy, Vels school of pharmaceutical sciences, Vels University, Pallavaram, Chennai – 600 043, Tamil Nadu, India.
2Department of pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600 116, Tamil Nadu, India.*Corresponding author.
*Mrs. Malarkodi Velraj
Department of Pharmacognosy,
Vels school of pharmaceutical sciences,
Vels University, Pallavaram,
Chennai – 117,
Tamil Nadu, India.
Received on: 20-07-2009; Revised on: 21-08- 2009; Accepted on:15-10-2009-
View Article File in pdf format.
Article File
-
View Article Citation Here.
6 View More -
How to Cite my Article.
Author: Malarkodi Velraj *1, A. Vijayalakshmi1, S. Jayakumari1, S. Ramamoorthy1,V. Ravichandiran1 & J.Srikanth2.
Title: Antidepressant activity of the ethanolic extract of Albizzia lebbeck (Linn) bark in animal models of depression Journal: Drug Invention Today Vol(issue): 1(2) Year: 2009 Page No: (112-115) -
Experimental Methods Keywords
Methodology: Antidepressant activity,Depression, Forced swim test, Tail suspension test. Research Materials: Albizzia lebbeck (Linn) bark
Keywords
Our Services
- Ethosomes: A novel tool for drug delivery through the skin
- Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats
- Evaluation of Phenolic Content and Antioxidant Capacity of leaf extract from Phoenix Dactylifera L obtained by different pH of aqueous extraction
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Biological synthesis of silver nanoparticles using aqueous leaf extract of Capparis decidua (FORSK.) EDGEW: A better alternative
- Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats
- Study of health related quality of life in rheumatoid arthritis patients
- In vitro antioxidant, anti-inflammatory and anticholinesterase activities of Rumex vesicarius L
- Prescribing Patterns of antihypertensive drugs in a South Indian tertiary care hospital
- In vitro anti-Candida activity of Calotropis gigantea.
- Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study.
- Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
- Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
- Anti ulcer activity of Naravelia zeylanica leaves extract
- Pharmacognostic, Phytochemical & Quantitative Investigation of Saraca asoca leaves
- Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent
- Effects of Osmolytes on The Structural Stability of Bovine Trypsin: A Brief Review
- Genome of Acinetobacter baumannii Carries Multi Drug Resistance Genes
- Triazole analogues as novel antioxidants: In vitro bioassay and molecular modeling studies
- In vitro antioxidant and ptp inhibitory activity of methanolic extract of Anogeissus acuminata leaf and bark.
- In vitro Antioxidant Activity from Leaves of Oroxylum indicum (L.) Vent. -A North Indian Highly Threatened and Vulnerable Medicinal Plant
- Anticonvulsant And Antioxidant Actions Of Some Dibenzo-a-Pyrone Derivatives In Pentylene –Induced Kindling Model In Mice
- FORMULATION AND IN VITRO EVALUATION OF NIOSOME ENCAPSULATED ACYCLOVIR
- Assessment of Pharmacognostical Characters of Leaves of Tephrosia Purpurea Linn
- Phytochemical Screening and Evaluation of Polyphenols, Flavonoids and Antioxidant Activity of Prunus cerasoides D. Don Leaves
- Formulation and Evaluation of Fast Dissolving Tablets of Ranitidine Hydrochloride