Journal: Drug Invention Today
Title: Antidepressant activity of the ethanolic extract of Albizzia lebbeck (Linn) bark in animal models of depression
Category: Pharmacological Screening
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Abstract
Objectives: The present study was designed to investigate the antidepressant effects of Albizzia lebbeck bark in various animal depression models.Materials and Methods: The alcoholic extract (70% v/v ethanol) of Albizzia lebbeck bark (200 & 400 mg/kg. p.o) was administered once daily for seven successive days to separate groups of young male swiss albino mice. The immobility periods of control and treated mice were recorded in two behavioral despair models forced swim test (FST), tail suspension test (TST) and the effect of extract on locomotor function of mice was studied using actophotometer. The antidepressant-like effect of tested drug was compared to that of imipramine (15 mg/ kg. p.o) and fluoxetine (20mg/kg.p.o). Results: The bark extract at doses of 200 and 400 mg/kg significantly decreased the duration of immobility time in a dose dependent manner in both FST and TST. The extract did not show significant effect on locomotor activity of mice. The efficacy of tested extract was found to be comparable to that of imipramine and fluoxetine. Conclusion: Our results suggested that the ethanolic extract of Albizzia lebbeck bark exerts antidepressant-like effect.
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About the authors and Affiliations
Author(s) Name: Malarkodi Velraj *1, A. Vijayalakshmi1, S. Jayakumari1, S. Ramamoorthy1,V. Ravichandiran1 & J.Srikanth2.
Affiliation(s) Name: 1*Department of Pharmacognosy, Vels school of pharmaceutical sciences, Vels University, Pallavaram, Chennai – 600 043, Tamil Nadu, India.
2Department of pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600 116, Tamil Nadu, India.*Corresponding author.
*Mrs. Malarkodi Velraj
Department of Pharmacognosy,
Vels school of pharmaceutical sciences,
Vels University, Pallavaram,
Chennai – 117,
Tamil Nadu, India.
Received on: 20-07-2009; Revised on: 21-08- 2009; Accepted on:15-10-2009-
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Author: Malarkodi Velraj *1, A. Vijayalakshmi1, S. Jayakumari1, S. Ramamoorthy1,V. Ravichandiran1 & J.Srikanth2.
Title: Antidepressant activity of the ethanolic extract of Albizzia lebbeck (Linn) bark in animal models of depression Journal: Drug Invention Today Vol(issue): 1 (December) Year: 2009 Page No: (112-115) -
Experimental Methods Keywords
Methodology: Antidepressant activity,Depression, Forced swim test, Tail suspension test. Research Materials: Albizzia lebbeck (Linn) bark
Keywords
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