Journal: Drug Invention Today
Title: Optimization of mouth dissolving meloxicam tablets prepared by sublimation technique
Category: Drug (Discovery/Development)
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Abstract
The aim of this investigation was to develop mouth dissolving tablets of Meloxicam. Granules containing Meloxicam, menthol, crospovidone and mannitol were prepared by wet granulation technique. Menthol was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed in to tablets. Alternatively, tablets were first prepared and later exposed to vacuum. The tablets were evaluated for percentage friability and disintegration time. A 32 full factorial design was applied to investigate the combined effect of two formulation variables: amount of menthol and crospovidone. The results of multiple regression analysis indicated that for obtaining mouth dissolving tablets; optimum amount of menthol and higher percentage of crospovidone should be used. Surface response plots are also presented to graphically represent the effect of the independent variables on the percentage friability and disintegration time. The validity of a generated mathematical model was tested by preparing a checkpoint batch. Sublimation of menthol from tablets resulted in rapid disintegration as compared with the tablets prepared from granules that were exposed to vacuum. Hence, it was concluded that mouth dissolving tablets with improved meloxicam dissolution could be prepared by sublimation of tablets containing suitable subliming agent.
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About the authors and Affiliations
Author(s) Name: Ramnik Singh*, Jyotsana Madan**
Affiliation(s) Name: *Department of Pharmaceutics,Khalsa College of Pharmacy, Amritsar-143002, Punjab, India
**Department of Pharmaceutics,Sri Sai College of Pharmacy, Bdhani, Pathankot, Gurdaspur, Punjab, India*Corresponding author.
Ramnik Singh
Department of Pharmaceutics
Khalsa College of Pharmacy, Amritsar, -143002, Punjab, India
Received on: 20-05-2009; Revised on: 21-06- 2009; Accepted on:15-07-2009-
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Author: Ramnik Singh*, Jyotsana Madan**
Title: Optimization of mouth dissolving meloxicam tablets prepared by sublimation technique Journal: Drug Invention Today Vol(issue): 1 (December) Year: 2009 Page No: (144-149) -
Experimental Methods Keywords
Methodology: Mouth dissolving tablets,factorial design, response surface plot,sublimation technique Research Materials: Meloxicam
Keywords
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