Journal: Drug Invention Today

Article Id: JPRS-PS-0000870
Title: Analgesic, Antipyretic and Anti-inflammatory Effect of the Whole Plant Extract of Desmostachya bipinnata Stapf (Poaceae) in Albino Rats
Category: Pharmacological Screening
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    Analgesic, Antipyretic and anti-inflammatory effect of petroleum ether, benzene chloroform, ethanol and aqueous extract of the whole parts of Desmostachya bipinnata Stapf (Poaceae) was investigated in albino rats. Animals were given a subcutaneous injection of 12% w/v suspension of yeast (1ml /100gm Body weight) suspended in 0.5% w/v methylcellulose solution which leads to pyrexia. Oral administration of petroleum ether, chloroform, ethanol and aqueous extract of the whole parts of Desmostachya bipinnata Stapf (Poaceae) at a dose 300 mg/ kg body weight into six groups of animal for both the activities were shown significantly reduce the elevated body temperature of rat which was compared with standard paracetamol (marketed product) and diclofenac sodium respectively. The anti-inflammatory activity was evaluated by using Digital plethysmometer. The study was carried out using dose of 300 mg/kg orally. All the extracts produced statistically significant and dose dependent inhibition of edema induced by carrageenan at all doses when compared to the control groups.

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    Author(s) Name:

    Somezeet Panda1*, N. S. K Choudhury 2, V. Jagannath Patro3, Dipti Kanta Pradhan, Goutam Kumar Jana1

    Affiliation(s) Name:

    *1Department of Pharmacy, Gayatri College of Pharmacy, Jamadarpali, Sason, Sambalpur, Orissa, 768200,India
    2 Pharmacy Wing, SCB Medical College, Cuttack, Orissa, India
    3 Department of Pharmachemistry,College of Pharmaceutical Sciences, Mohuda, Berhampur, Ganjam, Orissa, India

    *Corresponding author.
    Mr. Somezeet Panda,
    Department of Pharmacy,
    Gayatri College of Pharmacy,
    Jamadarpali, Sambalpur, Sason,
    Orissa, 768200, India


    Received on: 20-05-2009; Revised on: 21-06- 2009; Accepted on:15-07-2009

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    Author:

    Somezeet Panda1*, N. S. K Choudhury 2, V. Jagannath Patro3, Dipti Kanta Pradhan, Goutam Kumar Jana1

    Title:Analgesic, Antipyretic and Anti-inflammatory Effect of the Whole Plant Extract of Desmostachya bipinnata Stapf (Poaceae) in Albino Rats
    Journal:Drug Invention Today
    Vol(issue):1 (December)
    Year:2009
    Page No: (150-153)
  • Experimental Methods Keywords

    Methodology:Analgesic, Antipyretic and Anti-inflammatory Activity
    Research Materials:Desmostachya bipinnata Stapf

Keywords

Desmostachya bipinnata Stapf Analgesic Antipyretic and Anti-inflammatory Albino Rat Yeast Diclofenac sodium Paracetamol.

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