Journal: Drug Invention Today
Title: Formulation and Evaluation of Gastro retentive Floating Drug Delivery System of Ofloxacin
Category: Drug (Discovery/Development)
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
The objective of this present study is to formulate and evaluate the gastroretentive floating drug delivery system (GRFDDS) of ofloxacin prepared by using synthetic and natural polymers (polyethylene oxide and gum karaya). Formulations were prepared by wet granulation technique and sodium bicarbonate (10% w/w) was incorporated as gas generating agent. Tablets were evaluated for hardness, in vitro buoyancy, drug content and in vitro drug release studies. Release data obtained was subjected to analysis using different mathematical models namely – zero order flux, first order, erosion plot, Higuchi and Korsmeyer peppas equations. All formulated tablets irrespective of polymer used had hardness and friability values >5.0kg/cm2 and <0.68%. The in vitro lag time and total buoyancy time for all the formulations
were between 45 to 183secs and 5 to 16 hrs respectively. As the concentration of the polymers in the formulations increased the drug release decreased. Formulations made with gum karaya exhibited first order kinetics, non- fickian diffusion and the formulations like OGK3 and OGK4 followed first order and erosion mechanism. Whereas polyethylene oxide based formulations OP2,OP4 and OP5 exhibited zero order, non fickian diffusion and remaining formulations followed first order, erosion mechanism. GRFDDs of ofloxacin using synthetic (polyethylene oxide) and natural polymer (gum karaya) with drug to polymer ratio 1:0.5 and 1: 0.625 respectively are final optimized formulations. These were further characterized by Fourier transform infrared spectroscopy (FTIR) which indicated that there was no interaction
between drug and polymers. -
Abstract Audio
About the authors and Affiliations
Author(s) Name: M V Srikanth*1, N Sreenivasa Rao1, S A Sunil1, G S Sharma1, M U Uhumwangho2, and K V Ramana Murthy1
Affiliation(s) Name: 1 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.
2 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria.*Corresponding author.
M V Srikanth
University College of Pharmaceutical Sciences,
Andhra University, Visakhapatnam-530003, India.
Received on: 15-06-2010; Revised on: 09-07- 2010; Accepted on:06-02-2011-
View Article File in pdf format.
Article File
-
View Article Citation Here.
12 View More -
How to Cite my Article.
Author: M V Srikanth*1, N Sreenivasa Rao1, S A Sunil1, G S Sharma1, M U Uhumwangho2, and K V Ramana Murthy1
Title: Formulation and Evaluation of Gastro retentive Floating Drug Delivery System of Ofloxacin Journal: Drug Invention Today Vol(issue): 3 (March) Year: 2011 Page No: (7-9) -
Experimental Methods Keywords
Methodology: Formulation and Evaluation Research Materials: Ofloxacin
Keywords
Our Services
- Evaluation of pulmonary function test in construction workers
- Investigations on purification ,characterization and antimicrobial activity of enzyme papain from Carica papaya Linn.
- Antibacterial activity of different endodontic sealers: An in vitro evaluation
- Effectiveness of good behavior game on oral health among children - A randomized trial
- Effect of music on academic performance of college students
- Estimation of Tizanidine HCl by UV-Spectrophotometric Method
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Medicinal uses of banana (Musa paradisiaca)
- The role of toponymic objects in the system of settlement and reconstruction of landscapes in the Pre-Volga Region of the Republic of Tatarstan
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Biodegradable plastic production from corn starch
- Effects of lupeol on insulin receptor and glucose transporter-4 in cardiac tissue of Type-2 diabetic rats
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Formulation and evaluation of solid dispersions of valsartan for dissolution rate enhancement
- Simultaneous Spectrophotometric Estimation of Paracetamol and Aceclofenac in Combined Tablet Formulations using Hydrotropic Solubilization Technique
- Aspergillus Derived Silver Nano Particles as a Potent Antibacterial Agent and Identification of Linked Proteins
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Formulation and Evaluation of Sildenafil Citrate Fast Dissolving Tablets Using Crospovidone and Croscarmellose Sodium Superdisintegrants
- Assortment of vital nutrients for enhancement of Cyclodextrin glycosyltransferase produced by Bacillus amyloliquefaciens KST5: A Plackett-Burman design approach
- Fomulation and Evaluation of Taste Masked Spherical Agglomerates of Telmisartan
- Comparative Study of Ionotropic Gelation Technique To Entrap Diltiazem HCl In Mucoadhesive Microparticulate System.
- Validation of Uv Spectrophotometric method for estimation of Levocetirizine Dihydrochloride in bulk and pharmaceutical formulation
- Novel Controlled Gastroretentive Drug Delivery Systems: A Review
- In vitro antibacterial activity of essential oils of selected herbals against isolates from HIV/AIDS patients
- Preparation and Characterization of Pharmaceutical Grade Chitosan And Hydrated Chitosan Gums for Topical Preparations
- Antiulcer activity of aqueous suspension of Saraca indica flower against gastric ulcers in albino rats
- In silico and in vivo approach to identify the antidiabetic activity of lupeol
- Ethosomes: A novel tool for drug delivery through the skin
- A Case Study on Zinc Phosphide Poisoning in Tamil Nadu