Journal: Drug Invention Today
Title: Formulation and Evaluation of Gastro retentive Floating Drug Delivery System of Ofloxacin
Category: Drug (Discovery/Development)
Section: Research Article
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Abstract
The objective of this present study is to formulate and evaluate the gastroretentive floating drug delivery system (GRFDDS) of ofloxacin prepared by using synthetic and natural polymers (polyethylene oxide and gum karaya). Formulations were prepared by wet granulation technique and sodium bicarbonate (10% w/w) was incorporated as gas generating agent. Tablets were evaluated for hardness, in vitro buoyancy, drug content and in vitro drug release studies. Release data obtained was subjected to analysis using different mathematical models namely – zero order flux, first order, erosion plot, Higuchi and Korsmeyer peppas equations. All formulated tablets irrespective of polymer used had hardness and friability values >5.0kg/cm2 and <0.68%. The in vitro lag time and total buoyancy time for all the formulations
were between 45 to 183secs and 5 to 16 hrs respectively. As the concentration of the polymers in the formulations increased the drug release decreased. Formulations made with gum karaya exhibited first order kinetics, non- fickian diffusion and the formulations like OGK3 and OGK4 followed first order and erosion mechanism. Whereas polyethylene oxide based formulations OP2,OP4 and OP5 exhibited zero order, non fickian diffusion and remaining formulations followed first order, erosion mechanism. GRFDDs of ofloxacin using synthetic (polyethylene oxide) and natural polymer (gum karaya) with drug to polymer ratio 1:0.5 and 1: 0.625 respectively are final optimized formulations. These were further characterized by Fourier transform infrared spectroscopy (FTIR) which indicated that there was no interaction
between drug and polymers. -
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About the authors and Affiliations
Author(s) Name: M V Srikanth*1, N Sreenivasa Rao1, S A Sunil1, G S Sharma1, M U Uhumwangho2, and K V Ramana Murthy1
Affiliation(s) Name: 1 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.
2 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria.*Corresponding author.
M V Srikanth
University College of Pharmaceutical Sciences,
Andhra University, Visakhapatnam-530003, India.
Received on: 15-06-2010; Revised on: 09-07- 2010; Accepted on:06-02-2011-
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Author: M V Srikanth*1, N Sreenivasa Rao1, S A Sunil1, G S Sharma1, M U Uhumwangho2, and K V Ramana Murthy1
Title: Formulation and Evaluation of Gastro retentive Floating Drug Delivery System of Ofloxacin Journal: Drug Invention Today Vol(issue): 3 (March) Year: 2011 Page No: (7-9) -
Experimental Methods Keywords
Methodology: Formulation and Evaluation Research Materials: Ofloxacin
Keywords
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