Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00009
Title: Antihyperlipidemic Activity of Premna corymbosa (Burm.f.) Rottl. & Willd. in liver Damaged Wistar Albino Rats
Category: Pharmacology
Section: Research Article
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    The Premna corymbosa is a common plant, it is used in various ayurvedic preparations. The aim of the  present study is to evaluate the antihyperlipidemic activity of Premna corymbosa leaves in CCl4 induced hepatic  damaged rats.Liver was damaged in wistar rats of both sex by intraperitoneal injection of CCl4 in the concentration of 1 ml/kg body weight for every 72 h. The ethanolic extract of Premna corymbosa leaves were administrated at the  doses of 200 & 400 mg/kg body weight, p.o., daily for 14 days. The Antihyperlipidemic effect of the ethanolic extract  was assessed by the assay of the biochemical parameters like serum triglycerides (STG), serum total cholesterol  (STC) and Very low density lipoprotein cholesterol (VLDL-c).The ethanolic extract, significantly (p<0.01) restored the levels of biochemical parameters as compared to normal. The results obtained shows that the ethanolic extract of  Premna corymbosa has antihyperlipidemic property.

    Cite this article as: Karthikeyan.M*1 , Deepa .M.K2,Antihyperlipidemic Activity of Premna corymbosa (Burm.f.) Rottl. & Willd. In liver Damaged Wistar Albino Rats 63 Journal of Pharmacy Research Vol.1.Issue 1. July-September 2008 61-64.

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    Author(s) Name:

    Karthikeyan.M*1, Deepa .M.K2

    Affiliation(s) Name:

    1 Department of Pharmacology,Malik Deenar College of Pharmacy, Seethangoli, Bela Post, Kasaragod –671321, 
    Kerala State , India . 
    2 Department of Pharmaceutics, JDT Islam College of Pharmacy, Marikkunnu, Jamiath hill, Malabar, Calicut - 673012, Kerala State, India. 


    For correspondance:

    Karthikeyan.M,Department of Pharmacology,Malik Deenar College of Pharmacy, 
    Seethangoli, Bela Post, Kasaragod –671321, Kerala State , India . 
    E-Mail: karthikeyanpgt@gmail.com, deepa81mk@yahoo.co.in 


    Received on: 22-05-2008; Accepted on :27-07-2008

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    Author:

    Karthikeyan.M*1, Deepa .M.K2

    Title:Antihyperlipidemic Activity of Premna corymbosa (Burm.f.) Rottl. & Willd. in liver Damaged Wistar Albino Rats
    Journal:Journal of Pharmacy Research
    Vol(issue):1 (July-September 2008)
    Year:2008
    Page No: (61-64)
  • Experimental Methods Keywords

    Methodology:Antihyperlipidemic Activity
    Research Materials:Premna corymbosa (Burm.f.) Rottl. & Willd.

Keywords

Premna corymbosa leaves ethanolic extract liverdamage Antihyperlipidemic activity.

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