Journal: Drug Invention Today

Article Id: JPRS-D(DD)-0000900
Title: Formulation and evaluation of topical gel of diclofenac sodium using different polymers
Category: Drug (Discovery/Development)
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  • Abstract

    A wide choice of vehicles ranging from solids to semisolids form has been used for skin care and topical treatment of dermatological disease, High molecular weight water soluble polymers of Hydroxypropyl methylcellulose (HPMC), Carbapol 934P, Sodium alginate that possess very high viscosity, transparency, film forming properties at low concentration, are reported to useful in formation of gel. In the present investigation Diclofenac sodium gels were prepared for topical drug delivery by using different concentration of HPMC, Sodium alginate, Carbapol 934P, with an objective to increase transparency and spreadability. From the study it was concluded that HPMC gel containing Diclofenac sodium showed good consistency, homogeneity, spreadability and stability and has wider prospect for topical preparations as compared to Sodium alginate, Carbapol 934P gel containing Diclofenac sodium.

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  • About the authors and Affiliations

    Author(s) Name:

    A Gupta1*, AK Mishra2, AK Singh1, V Gupta2, P Bansal3

    Affiliation(s) Name:

    1Babu Banarasi Das National Institute of Technology and Management, Lucknow, India
    2 National Institute of Ayurvedic Pharmaceutical Research, CCRAS, Patiala, India
    3 Baba Farid University of Health Sciences, Faridkot, India

    *Corresponding author.
    A Gupta
    Babu Banarasi Das National Institute of Technology
    and Management,
    Lucknow, India


    Received on: 15-01-2010; Revised on: 15-03- 2010; Accepted on:15-04-2010

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    Author:

    A Gupta1*, AK Mishra2, AK Singh1, V Gupta2, P Bansal3

    Title:Formulation and evaluation of topical gel of diclofenac sodium using different polymers
    Journal:Drug Invention Today
    Vol(issue):2(5)
    Year:2010
    Page No: (250-253)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation, Topical drug delivery
    Research Materials:Diclofenac sodium

Keywords

Topical drug delivery Diclofenac sodium HPMC Carbapol 934P Sodium alginate

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