Journal: Drug Invention Today

Article Id: JPRS-D(DD)-0000914
Title: Recent advances in self emulsifying drug delivery system - A review
Category: Drug (Discovery/Development)
Section: Review Article
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    Self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. From time to time many workers have claimed various rational applications of Self-emulsifying formulation for enhancing bioavailability and site-specific targeting of highly lipophilic drugs. SEDDS is ideally an isotropic mixture of oils and surfactants and sometimes co solvents. The multi-component delivery systems have optimized by evaluating their ability to self-emulsify when introduced to an aqueous medium under gentle agitation, and by determination of particle size of the resulting emulsion. Upon per oral administration, these systems form fine (micro) emulsions in the gastrointestinal tract (GIT) with mild agitation provided by gastric mobility. These articles
    give an overview of the recent advances in the development of SEDDS and the dosage forms along with the associated problems and the possible future research directions in this field.

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    Author(s) Name:

    A Pathak*1, V Jain1, AK Nagariya1, R Singh1, S Nayak2, P Bansal3, V Gupta3, S Kumar3, Harinder Singh4

    Affiliation(s) Name:

    1School of Pharmaceutical Sciences, Meerut, India
    2Bansal College of Pharmacy, Bhopal, India
    3National Institute of Ayurvedic Pharmaceutical Research, Patiala, India
    4Goverment Medical College, Patiala, India

    *Corresponding author.
    Amresh Pathak,
    School of Pharmaceutical Sciences, Meerut, India


    Received on: 20-05-2009; Revised on: 21-06- 2009; Accepted on:15-07-2009

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    Author:

    A Pathak*1, V Jain1, AK Nagariya1, R Singh1, S Nayak2, P Bansal3, V Gupta3, S Kumar3, Harinder Singh4

    Title:Recent advances in self emulsifying drug delivery system - A review
    Journal:Drug Invention Today
    Vol(issue):2 (February)
    Year:2010
    Page No: (123-129)
  • Experimental Methods Keywords

    Methodology:Self-emulsifying drug delivery systems (SEDDS)
    Research Materials:Synthetic drugs

Keywords

Self-emulsifying drug delivery systems (SEDDS) Surfactants Self-emulsification GIT.

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