Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-000092
Title: Evaluation of anti-nociceptive properties of Drynaria quercifolia rhizome in Swiss-albino mice
Category: Pharmacology
Section: Research Article
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    Objective: Screening of methanolic crude extracts of Drynaria quercifolia rhizome (Family: Polypodiaceae) and its different solvent soluble fractions for possible anti-nociceptive activities in experimental Swiss-albino mice. Methods: Anti-nociceptive activity was evaluated by acetic acid induced writhing inhibition and radiant heat tail-flick methods. Results: In peripheral method of anti-nociception, the methanolic crude extract (400 mg/kg) and carbon tetrachloride fraction (400 mg/kg) of D. quercifolia showed significant anti-nociceptive activity having 40.94% and 45.64% (P<0.001) of writhing inhibition respectively compared to standard diclofenac (51.68 % inhibition). The aqueous soluble fraction of the extract (400 mg/kg) also showed promising anti-nociceptive activity having 34.9% of writhing inhibition (P<0.001). In the radiant heat tail-flick method of central anti-nociception, the methanolic crude extract (400 mg/kg) and petroleum ether fraction (400 mg/kg) of D. quercifolia showed significant analgesic activity having 63.92% (P<0.001) and 64.49% (P<0.01) elongation of reaction time respectively at 60 minutes after administration of sample compared to the standard morphine (75% elongation). The carbon tetrachloride fraction (400 mg/kg) also demonstrated potent analgesic activity (51.14% elongation). Conclusion: The findings of the studies demonstrated anti-nociceptive activities of the rhizomes of D. quercifolia which could be the therapeutic option against pain.

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    Author(s) Name:

    Milon C Mohanta1, Amlan Ganguly2, Farida Begum1, S. M. Abdur Rahman1*

    Affiliation(s) Name:

    1. Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
    2. Department of Pharmacy, Faculty of life & Earth Science, Jagannath University, 10 Chittaranjan Avenue, Dhaka-1100, Bangladesh.

    *Corresponding author.
    S. M. Abdur Rahman Ph.D.
    Professor,
    Department of Clinical Pharmacy & Pharmacology,
    Faculty of Pharmacy,
    University of Dhaka,
    Dhaka-1000, Bangladesh.
    E-mail: rahman_du@yahoo.com

    Received on:22-11-2013; Revised on: 11-12-2013; Accepted on:19-12-2013

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    Author:

    Milon C Mohanta1, Amlan Ganguly2, Farida Begum1, S. M. Abdur Rahman1*

    Title:Evaluation of anti-nociceptive properties of Drynaria quercifolia rhizome in Swiss-albino mice
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (January )
    Year:2014
    Page No: (41-44)
  • Experimental Methods Keywords

    Methodology:Writhing inhibition, Percent time elongation, Radiant heat tail flick method.
    Research Materials:Drynaria quercifolia

Keywords

Drynaria quercifolia Writhing inhibition Percent time elongation Radiant heat tail flick method.

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