Journal: Drug Invention Today

Article Id: JPRS-PS-0000920
Title: Evaluation of anti-inflammatory potential of Trigonella foenum-graecum (Fenugreek) seed extracts by using carrageenan induced rat paw edema
Category: Pharmacological Screening
Section: Research Article
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    The aim of this study was to evaluate the anti-inflammatory potential of Trigonella foenum – graecum (TFG) seed extracts by using carrageenan induced rat paw edema in comparison to established anti-inflammatory drug diclofenac potassium (DIP, 10 mg/kg, p.o.). Successively extracted (aqueous and ethanol) extracts of TFG seeds were administered 1 h prior to inflammation induction in dose range of 50, 100 and 200mg/kg orally. The rat paw edema was induced by injecting 0.1 ml of 1 % w/v carrageenan solution, prepared with normal saline in subplantar region of left hind paw of the rats.Results of these study revealed that the ethanol extract at dose 200 mg/kg shows significant (p<0.01) reduction of inflammation as compared to aqueous extract group animals. Further series of investigations are, however, necessary to explore their mechanism(s) of action involved in this pharmacological activity.

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    Author(s) Name:

    Kapil G. Malviya1,*, Mukesh W. Babhulkar2, Prashant Y. Mali3 and Vinod D. Rangari4

    Affiliation(s) Name:

    1,*Department of Pharmacognosy, Radharaman Institute of Pharmaceutical Sciences, Ratibad, Bhopal-462043 (M.P.), India
    2Department of Pharmaceutics, Radharaman Institute of Pharmaceutical Sciences, Ratibad, Bhopal-462043 (M.P.), India
    3Department of Pharmacology, Radharaman College of Pharmacy, Ratibad, Bhopal-462043 (M.P.), India
    4J. L. Chaturvedi College of Pharmacy, Nagpur-440016, M.S, India.

    *Corresponding author.
    Kapil G. Malviya
    Department of Pharmacognosy,
    Radharaman Institute of Pharmaceutical Sciences,
    Ratibad, Bhopal-462043 (M.P.), India


    Received on: 10-10-2009; Revised on: 08-12- 2009; Accepted on:08-01-2010

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    Author:

    Kapil G. Malviya1,*, Mukesh W. Babhulkar2, Prashant Y. Mali3 and Vinod D. Rangari4

    Title:Evaluation of anti-inflammatory potential of Trigonella foenum-graecum (Fenugreek) seed extracts by using carrageenan induced rat paw edema
    Journal:Drug Invention Today
    Vol(issue):2 (February)
    Year:2010
    Page No: (109-111)
  • Experimental Methods Keywords

    Methodology:anti-inflammatory activity
    Research Materials:Trigonella foenum- graecum (TFG)

Keywords

Anti-inflammatory potential Carrageenan Trigonella foenum- graecum (TFG) Fenugreek Seeds Digital Vernier Caliper..

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